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The authors generalize the literature data and present the original findings on development features and pathogenetic role of cardiomyocyte apoptosis in acute myocardial infarction and Post−Infarction heart remodeling in diabetes mellitus.

Based on the review of the up−to−date literature, it is concluded that administration of Amiodarone and its combinations with antiarrhythmic IC drugs can reduce the frequency of stroke and death as well as to improve the quality of life of the patients with atrial fibrillation.

The literature data about the clinical−morphological signs of myocardial bridges with systolic compression of the coronary arteries are presented; the informativity of various diagnostic techniques is evaluated. The original findings of myocardial bridges observation are reported.

The mechanisms of forming and manifestation of sex and love addiction as well as associated reference addiction and avoidance addiction are featured. The author emphasizes the necessity to know them for working out the system of psychocorrection of this pathology.

Casual relations between secondary sexual dysfunction in women and neurotic disorders, impairment of a mature personality and forming variants of sexual deadaptation of a marries couple are featured. The author concludes about the necessity to consider the revealed regularities when working out the system for psychotherapeutic correction.

The questions of detoxification and metabolic disorders correction in schizophrenia treatment with Reambirin are discussed. The obtained findings allow to consider that the use of Reambirin in this diseases is pathogenetically substantiated.

The original system for psychoprophylaxis of sexual health disorders and solitude of divorced men is presented. The principles of psychoprevention are reported. The methods and essence of the psychopreventive measures are described in detail. The reality of their use in practice is emphasized.

The study of the spectrum and sensitivity to antibiotics used in acute and exacerbations of chronic maxillary sinusitis was done. The increase of microorganism resistance to penicillins and preservation of high sensitivity of fluoroquinolones to main agents of purulent sinusitis were noted. The authors conclude about the necessity to use physical factors with a nonspecific antibacterial effect in addition to antimicrobial drugs.

Administration of immunomodulator Erbisol was shown to result in elimination of clinical manifestations of the disease and normalizing a number of immune parameters in chronic laryngitis accompanied by autoimmune thyroiditis. It is concluded about the expediency to administer the drug in complex treatment for this disease.

Up−to−date concepts of fibrogenesis are featured. The most practical classifications of chronic pancreatitis are described. The disease diagnosis is discussed. Special attention is paid to surgical methods of treatment including modern draining operations, organ−saving and subtotal resections.

The outcomes of surgical rehabilitation of colostomy patients are analyzed. The object of surgical rehabilitation in the patients with a life−long stoma was shown to be treatment of the complications associated with the colostomy. The object of rehabilitation of the patients with temporary colostomy is restoration of intestinal continuity by means of reconstructive−restorative surgery. Only medical rehabilitation is emphasized to be able to solve the whole range of the problems in colostomy patients. The state support in supply of the modern stoma equipment is necessary.

The original physical model of the cervical spine representing its anatomical, biomechanical and functional features is described in detail. The model allows to study the character of the load distribution in the soft−tissue elements of the cervical spine in accordance with its biomechanical features in various regimens of use of external force and after modelling various variants of spondylodesis at the level of fixation and in the adjacent segments.

Based on the principles of integrative medicine, systemic approach with the use of concept of logical modelling, a uniform system of concepts about the diseases of the hip joint in children with hereditary susceptibility was worked out. It was shown that the suggested integrative approach can be used for working out diagnostic and prognostic criteria of joint development and performing pathogenetic surgery aimed at elimination or reduction in the frequency of forming dysplastic coxarthrosis.

Up−to−date information about the etiology and pathogenesis of esophageal cancer is reviewed. The methods of the disease diagnosis and variants of therapeutic tactics are described.

The analysis of the changed clinical picture of renal tumors is done. The dynamics and sequence of the new imaging techniques are described.

The effect of hypolipidemia drug Simvastatin on the state of the vascular endothelium and blood lipids in limited scleroderma was studied. The use of Simvastatin in complex treatment of the disease is shown to improve the clinical course of the disease and to allow normalization of the majority of laboratory parameters. The obtained findings suggest pathogenetic substantiation of statins administration in treatment of organic scleroderma.

Epidemiological microsporia situation is Moscow is presented. The factors considerably influencing it are discussed. The effect of a special program of quantitative controlling recommendations for dermatology service is analyzed.

Considerable importance of the issue of urogenital chlamydiosis as well as its epidemiology and clinical manifestations are shown. Modern drugs and schemes are analyzed in detail. Clinical economical expertise of the treatment is done.

The findings of the study of clinical pathogenetic efficacy of Phosphogliv injections in HCV infection and mixed HCV+HBV infection are presented.

The contemporary approaches to diagnosis of chronic viral hepatitis are discussed. Puncture liver biopsy is described in detail, the original findings of histology study are presented.

The capabilities of virtual cystoscopy in diagnosis of the bladder tumors, its advantages vs optic cystoscopy as well as the prospects of this method of radiation diagnosis are shown.

Review of the literature data representing the current opinions on various methods of aseptic femur necrosis diagnosis in adults are reported. Their advantages and disadvantages are described in detail.

The possibility to prevent malignancy formation using nonsteroid anti−inflammatory drugs is discussed. The author concludes about the lack of data proving the possibility to use them for prevention and treatment of malignant diseases.

The urgency of the issue of calcium antagonists application in various fields of medicine is shown. Various drugs of this group, their clinical pharmacology, pharmacokinetics and efficacy are discussed.

The state of the question of training specialists for priority theoretical and applied research is analyzed. The necessity to work out a concept and methodology of forming clinical thinking in practicing doctors and abstract analytical−integral thinking in researchers are substantiated.

The factors influencing satisfaction of the patients with the treatment in a hospital for internal diseases are discussed. The authors conclude that satisfaction with the treatment is not less important than the quality of life of the patient.

The problems of health, quality of life and efficacy of medical care are discussed. The role of a high qualification of the doctors, reorganization of management system in health protection are emphasized. The approaches and methods of the quality and efficacy of medical care assessment are analyzed. The authors suggest revising the strategies of prevention, as well as to introduce the system of measures aimed at risk factors and their control.

The principles and standard quantitative algorithm for assessment of integral efficacy of work of the new organization models of primary medical sanitary care discussed using the example of a general practitioner's office created in a ambulatory office were worked out.