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№1' 2015


Congress of the European Society of Cardiology (Barcelona, 2014): results of the most important clinical trials
5 - 11
A report on all five scientific sessions Hot Line of the Congress of European Society of Cardiology in 2014, dedicated to non−cardiac surgery, hypertrophic cardiomyopathy, pulmonary embolism, −aortic disease, infarction revascularization is presented.
The role of Holter ECG monitoring in stratification of risk for sudden cardiac death in patients after myocardial infarction
12 - 17
The review analyzes the recent literature data on evaluation of prognostic value of individual indicators obtained by Holter ECG in stratification of risk of sudden cardiac death in patients after myocardial infarction.
The role of apelin in the pathogenesis of cardiovascular and gastrointestinal diseases
18 - 21
The data of Ukrainian and foreign literature on the study of a new protein regulator, apelin, in the pathogenesis of hypertension and diseases of the gastrointestinal tract are presented. Investigation of apelin properties suggests about its role in formation of a series of pathologies of the cardiovascular system with associated pathology of the gastrointestinal tract thus requiring further study.
Antihypertensive therapy effects from the perspective of evidence−based medicine
22 - 25
The main data about Pilot Project on Arterial Hypertension realization in Ukraine are represented. The necessity to consider the information concerning pharmacokinetics and pharmacodynamics, antihypertensive, antianginal and organ−protective effects of amplodipine when prescribing the medicine is emphasized. Common results about amlodipine apply in definite clinical cases are presented.
Echographic markers of vascular and cardiac disorders in patients with arterial hypertension and arterial hypertension associated with type 2 diabetes mellitus
26 - 31
The importance of studying the state of vessels and heart in patients with arterial hypertension and arterial hypertension associated with diabetes mellitus was analyzed. The most informative ultrasound indicators of the progression of vascular and cardiac dysfunction were selected. The indicators were divided into three classes: class 1 differentiates the norm and pathology, class 2 differentiates the norm, arterial hypertension and various stages of diabetes mellitus, class 3 is increased only in patients with diabetes mellitus.
A method of areflux isoperistaltic choledochojejunodoudenostomy
32 - 34
Modification of isoperistaltic biliodigestive anastomosis, which provides complete restoration of bile passage into the duodenum and prevents development of its erosive−ulcerative lesions, is presented. The technique of anastomosis formation allows prevention of enteric−digestive reflux, thus providing prevention of reflux cholangitis.
Dynamics of cytokine status indicators in patients with acute ulcerative gastroduodenal bleeding at surgical treatment
35 - 39
The article analyzes the state of cytokine status at surgical treatment of patients with acute ulcerative gastroduodenal hemorrhage. To assess cytokine status of the organism, blood serum concentration of TNFα, IFNγ, IL−1, IL−2, IL−4, IL−6, IL−8 and IL−10 was investigated. Imbalance of systemic and local cytokine status indicators at which surgery with basic conservative therapy does not result in its control and requires adequate cytokinotherapy was noted.
Prospects of cell therapy application in restoring contractile function of the operated fallopian tubes
40 - 44
The literature on treatment and postoperative rehabilitation of patients with ectopic pregnancy is reviewed. It is emphasized that the existing methods are not able to restore the anatomical and functional integrity of the fallopian tubes and ciliated secretory epithelium entirely. One of the methods of dead muscular fallopian tube cells substitution is therapy with stem cells, the earliest in the sequential chain of strictly regulated processes, which ensure formation and maintenance of the majority of adult human cell lines, namely, proliferation, migration, differentiation, maturation and apoptosis.
Aquaporins and their role in normal and pre−eclampsia placenta
45 - 49
The literature on the role of aquaporins in normal and pre−eclampsia placenta is reviewed. The findings of investigation of functions of aquaporins 1, 3, 8, 9 in regulation of the volume of amniotic fluid are reported. It is suggested that impaired expression of aquaporins in the fetal membranes may be associated with idiopathic polyhydramnios or oligohydramnios. The role of insulin, human chorionic gonadotropic hormone and cyclic adenosine monophosphate in the functional expression of aquaporin 9 is discussed. The hypotheses about the functional features of aquaporins require further investigation.
Prognostic significance of morphological parameters of renal cell carcinoma with intravenous invasion
50 - 53
The article reviews the literature on morphological prognostic parameters of renal cell carcinoma with macroscopic intravenous distribution. The results of the study of the factors responsible for biological aggressiveness of the primary tumor, proliferative activity indicators, apoptosis activity, and invasive growth and metastasis characteristics are discussed. The role of matrix metalloproteinases in the pathogenesis intravenous tumor spread is analyzed.
Drug therapy of lower urinary tract symptoms in patients with benign prostatic hyperplasia: what is new?
54 - 57
This study analyzes the changes in drug therapy of lower urinary tract symptoms associated with benign prostatic hyperplasia. New drugs and drug combinations were presented.
Current approaches to pathogenetic therapy of multiple sclerosis
58 - 62
The article provides an overview of the current literature on the pathogenetic therapy considering basic forms and types of multiple sclerosis; disputable questions about it are discussed. The data on the history of the study of multiple sclerosis, relevance of the problems in modern neuroscience, its clinical manifestations, epidemiological studies, the etiology and pathogenesis are presented.
Hyperkinesis in childhood pathology
63 - 67
The clinical manifestations of hyperkinetic syndrome in children from different age groups are reviewed. Depending on the level of brain damage, three groups of hyperkinesis were distinguished. Different types of hyperkinetic syndrome, their signs, pathogenesis, features are characterized. Particular attention is paid to differential diagnosis. An algorithm for examination of the children with hyperkinesis was suggested.
Clinical and neurological features of cerebral circulation disorders in young people
67 - 71
Cerebral circulation disorders were investigated in able−bodied persons. The complexity of the problem of stroke in young people due to lack of study of this disease, poor population information about the first symptoms and their consequences, which ranks first among the causes of primary disability, and adverse socio−economic situation. The article gives examples of clinical stroke in young people and methods of their treatment.
Blood plasma brain−derived neurotrophic factor (BDNF) in patients with subcortical vascular mild cognitive disorders: marker value for the diagnosis and therapy effectiveness evaluation
71 - 77
Blood plasma brain−derived neurotrophic factor (BDNF) levels were investigated in elderly and old patients with subcortical vascular mild cognitive disorders (SVMCD). Reduction of plasma BDNF levels correlated with some parameters of executive dysfunction, reflecting disorders of the link between the prefrontal cortex and subcortical structures due to microvascular brain lesions. Escitalopram treatment in patients with SVMCD led to increased level of plasma BDNF and general level of cognitive function by MMSE as well as simultaneous reduction of psychopathological disorders by Neuropsychiatric Inventory.
Psychogeniа аs main structural element of psychotherapeutic clinic
78 - 83
The article covers the clinical and theoretical interpretation and systematization of psychogenias as a fundamental component of psychotherapeutic clinic. Five levels of psychogenic disorders are described. The basic regularities of psychopathogenesis of these disorders were determined depending on the level of development. The role of psychogenias in formation of psychosomatic diseases was identified.
Features of emotional−affective sphere in patients with acute somatic diseases
84 - 88
The state of emotional−affective sphere of patients with acute conditions of somatic profile was investigated based on clinical, psychopathological and psycho−diagnostic study. The presence of common features had been noticed, namely absence of depressive symptoms, combination of a high level of trait anxiety and average of state anxiety, low levels of aggression and the average level of hostility. Differences in emotional−affective sphere of patients of different clinical groups were shown. The concept of pathogenesis−based system of medical and psychological correction was developed.
The organization of care for patients with autism spectrum disorders
89 - 91
The problem concerning both the diagnostic criteria for autism spectrum disorders, and their age characteristics is discussed. Social, psychological, social−psychological problems of patients with developmental disorders are shown. The methodological principles and methodological approaches of care for the patients with autism aimed at improvement of their quality of life were worked out.
Dynamics of the retinal nerve fibers layer thickness in the inferior quadrant in patients with primary open−angle glaucoma, treated by L−arginine
92 - 95
The aim of this study was to determine the dynamics of the retinal nerve fibers layer thickness in the inferior quadrant in patients with primary open−angle glaucoma primary open−angle glaucoma treated with L−arginine. The study involved 162 patients (287 eyes) with primary open−angle glaucoma. It was found that application of L−arginine in treatment of patients stabilized the retinal nerve fibers layer thickness in the inferior quadrant.
Seborrheic dermatitis: modern concept of pathogenesis
96 - 100
The information about the causes and underlying mechanisms of seborrheic dermatitis is presented. Particular attention is paid to the role of sex hormones in the occurrence and progression of dermatosis, infectious factors (skin colonization with Malassezia spp.) and immune disorders in development of the inflammatory response of the skin. The possible role of the innate immune factors and vitamin D in the disease pathogenesis is disused.
Molecular−genetic investigation of factors of growth at nonscarring alopecia
100 - 104
The distribution of polymorphisms of G−634C and G−1154A of gene VEGF was analyzed in patients with nonscarring alopecia. The observed distributions of heterozygotic genotypes of both loci significantly corresponded to those expected by Hardy − Weinberg law on balance. Low prognostic value of the investigated loci was noted.
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