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№2' 2015


The role of palmitic fatty acid in initiation of hypertriglyceridemia, hypercholesterolemia, atherosclerosis, and atheromatosis
5 - 14
The role of excessive palmitic fatty acid in the development of hyperlipoproteinemia, high cholesterol alcohol in low density lipoproteins, the pathogenesis of atherosclerosis and intimal atheromatosis formation were analyzed. The necessity to eliminate aphysiologically high content of palmitic acid in the diet was emphasized. The results can be used in the formation of the biological basis of cardiovascular diseases prevention.
Resistant arterial hypertension: diagnosis and treatment
15 - 23
Resistant arterial hypertension which is diagnosed when three antihypertensives administration does not result in achieving target arterial pressure is defined. Despite the prevalence of resistant arterial hypertension, lack of blood pressure control is often associated with an inadequate selection of antihypertensive therapy, incorrect blood pressure assessment or failure of patients to follow medical recommendations. Before taking diagnostic measures it is necessary to assess consistently the adequacy of the administered therapy as well as to exclude pseudoresistance.
Adipokines of adipose tissue and their role in progression of renal disease
24 - 28
The review analyzes updated research findings on the role of factors produced by adipocytes in obesity and accompanying metabolic, hormonal and hemodynamic changes in formation of pathological changes in the function and structure of the kidneys.
Relationship between daily blood pressure profile and a marker of chronic systemic inflammation in patients with stage 2 essential hypertension with microalbuminuria
29 - 33
The relationship between the mediators of chronic systemic inflammation in patients with stage 2 essential hypertension with microalbuminuria and the types of circadian systolic blood pressure was investigated. In the considered population the patients with insufficient degree of nocturnal systolic pressure reduction of the type "non−dipper" and "night−peaker" and significantly high pro−inflammatory (IL−6, TNF−α PSA) and anti−inflammatory (IL−10) cytokines level with the ratio of IL−6/IL−10 1.5 dominated.
The effect of intrauterine fetal infection on calcium and magnesium exchange in pregnant with urogenital infection
34 - 38
Serum calcium and magnesium levels in pregnant with urogenital infection of viral, bacterial and mixed etiology and their newborns were assessed. Moderate hypocalcemia in pregnant with intrauterine infection was shown to be associated with moderate hypomagnesaemia. Hypomagnesaemia in the mother results in decreased magnesium supply to the fetus as evidenced by its decreased contents in the umbilical blood.
Vitamin D deficiency in women with threatened miscarriage and bacterial vaginitis
39 - 42
The paper presents the results of investigation of vitamin D status in pregnant women with threa−tened preterm labor and bacterial vaginosis. It is shown that more than half of the investigated women had shortage of vitamin D, while a third of pregnant women had severe deficiency of vitamin D. Given this data, it can be assumed that vitamin D deficiency may be an additional risk factor for dysbiosis of genital mucosa.
Assessment of the effectiveness of isthmic cervical incompetence correction with laser Doppler flowmetry
43 - 46
Investigation of microcirculation in the epithelium of the cervix using laser Doppler flowmetry in 90 patients with the purpose to determine the effectiveness of various methods of correction for isthmic cervical incompetence (ICI) is presented. It was found that surgical correction (circular weld overlay and plastic peccary for vaginal cervix) resulted in rapid development of pathological changes in the microvasculature of the cervix, which may lead to various complications. Therapy using hyaluronic acid based fillers does not violate the functional state of the microvasculature of the cervix, reduces the risk of complications after ICI correction, and is delivered in pregravid period, which is preferable in terms of prevention of possible pregnancy complications.
Modern approaches to clinical diagnosis and treatment of static disorders of the spine and joints
47 - 51
The article presents the data about diagnosis and structure of the causes of leg length inequality in patients with pelvic asymmetries. High efficiency of computer−optical topography of dorsal trunk surfaces in the diagnosis of leg length inequality was established. The methods of treatment for pain syndrome, in particular orthopedic correction, extracorporal shock−wave therapy, are discussed.
Reparative methods of surgical treatment for defects in knee cartilage
52 - 55
It was proven experimentally that the greatest number of chondrogenesis progenitor cells is localized at the boundary of endosteum and the medullary canal. Reparative surgical technique for treatment of patients with chondromalacia of the articular cartilage was proposed. The clinical efficacy of medullary cavity arthroscopic microfracturing at grade 3 and 4 chondromalacia and subchondral tunneling was compared.
The use of medication and physiotherapy in cephalgic syndrome in patients with sequellae of brain injury
56 - 60
The effect of complex medical and physical therapy on patients with hemodynamic sequellae of mild brain injury, which decreased the quality of life on all scales of MOS SF−36 questionnaire, was investigated. The use of physical therapy and medical methods promoted the subjective and objective improvement of their condition. Significant strengthening of cerebral blood flow and reduction of vascular resistance indices, improvement of the quality of life were observed.
Antiphospholipid syndrome and acute сerebrovascular pathology in infants
61 - 65
Antiphospholipid syndrome (APS) is considered to be the cause of acute cerebrovascular disease in childhood. This article describes the variants, clinical features of APS in children, the main serological markers to diagnose the syndrome. Current recommendations for the treatment of APS in childhood are presented. A case of ischemic stroke against a background of antiphospholipid syndrome in a 10−months child is described.
Treatment of cerebral venous dyscirculatory encephalopathy in patients in the late period of closed craniocerebral injury
66 - 70
The results of treatment of 72 patients with cerebral venous pathology in the long term of closed craniocerebral injury with diosmin 600 mg and magnetophoresis with a 10 % solution of bromine at C8−Th2 are analyzed. It was noted that this method improved arterial and venous components of cerebral circulation, indicators of aerobic capacity, cardio−pulmonary reserve. This method is effective in patients with initial manifestations of the disease, to a lesser extent in patients with intracranial venous dystonia and is almost ineffective in patients with severe venous encephalopathy.
Investigation of biological molecules in the rhythm of hair follicles in patients with alopecia areata
71 - 74
Fibroblast growth factor (bFGF) and apoptosis factor (FasL) were investigated in patients with alopecia areata. Blood concentration of bFGF decreases, and FasL concentration increases significantly in these patients. The obtained findings for bFGF and FasL correlate with the disease severity and indicate a minute adjustment of life cycle phases in the hair follicles of proteins of FGF and FasL family.
A case of syphilitic aortitis complicated with aortic aneurysm
75 - 78
Clinical signs and symptoms of syphilitic aortitis complicated with aortic aneurysm are presented by the example of a case from the practice of the authors. Difficulties of this diagnosis are emphasized. Treatment protocol consisting of specific antisyphilis therapy and surgical correction is shown.
Pressing issues of angioprotector administration
79 - 85
Modern classifications of angiotropic drugs are featured; the molecular mechanisms of their action as well as the peculiarities of their entering to the systemic circulation, the issues of efficiency and safety of therapy with angioprotectors are summarized and analyzed.
Pressing issues of malaria prevention
86 - 89
Malarial prophylactic measures aimed at early detection, decontamination of patients and parasite carriers as well as fight against the pathogen's vector mosquitos. Several options of possible genetic modifications to the mosquito's genome, in particular, cultivation of infertile, transgenic or genetically modified mosquitoes resistant to malaria are presented. Several drugs are suggested for chemoprevention at traveling to endemic areas, the recommendations for their administration are given.
Type 1 bocavirus detection in children with clinical manifestations of acute respiratory viral infection
90 - 94
Investigation conducted within the period of 2011−2014 revealed bocavirus infection in Ukraine. Real−time polymerase chain reaction was used to analyze 458 samples of biological material from hospitalized children with acute respiratory viral infection acute respiratory viral infection for the presence of human bocavirus. Bocavirus DNA of bоcavirus was found in 23.5 % of children aged 1−7 years. Variety of clinical symptoms specific to pediatric patients with acute respiratory viral infection was established.
Etiopathogenic aspects and complex ultrasonography of endometrial hyperplastic processes
95 - 97
The analysis of the literature on the etiology and pathogenesis of endometrial hyperplastic processes is presented with the consideration of disturbances of hormonal profile, metabolism, local changes at the cellular and intercellular level, sensitivity of the receptor apparatus. The findings of complex ultrasonography of this disease are shown.
The capabilities of transvaginal ultrasonography in the diagnosis of background cervical diseases
98 - 102
The paper presents the data on the capabilities of transvaginal ultrasonography in the diagnosis of background cervical diseases such as endocervical hyperplasia, pseudoerrosion, chronic endocervicitis) that can long mask hyperplastic processes of the cervix.
Life dedicated to people (the 70th birthday of Kozhyn M. I.)
103 - 104
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