ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 24., Iss. 4, 2018, P. 35−38.
THE ROLE OF IMMUNOLOGICAL FACTORS OF INVASIVENESS IN THE PATHOGENESIS OF GENITAL ENDOMETRIOSIS
Kharkiv National Medical University, Ukraine
The work presents new factors of immunopathogenesis of endometriosis. Endometriosis is one of the most common gynecological diseases and affects, according to different authors, from 4 % to 15 % of women of reproductive age. The aim of the work was to study the effect of expression of the main factors of endometrial invasion −− matrix metalloproteinases, as well as adhesion molecules on the development and severity of endometriosis in women. 60 patients aged 19−45 years were examined. First clinical group (control) consisted of 30 healthy fertile women. The second clinical group consisted of 30 patients with external forms of genital endometriosis of grade I−II according to the classification of the American Fertility Society. In terms of examination, all patients had general clinical (anamnesis collection, gynecological examination), instrumental examination (ultrasound, medical−diagnostic laparoscopy, colposcopy) and special research methods. The object of special research methods was the study of the expression level of matrix metalloproteinases MMPs (MMP−2, MMP−9) and the content of adhesion molecules in peripheral blood and peritoneal fluid, which was obtained during laparoscopy. Studies have shown that the endometriosis progression accompanied by increase expression of metalloproteinases, changes in proteinases expression level have an effect on the remodeling of the underlying stroma, as well as increased expression in the tissues of peritoneum adhesins responsible for the formation of strong cell−to−cell contacts. Detection of the immune mechanisms that determine the increased invasion of endometrial cells significantly expands our understanding of the mechanisms of ectopic growth. The obtained new pathogenetic factors regulating the invasive abilities of the endometrial tissue can serve as a basis for the treatment of endometriosis.
Key words: endometriosis, invasiveness, metalloproteinases, adhesion molecules.