ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 24., Iss. 4, 2018, P. 39−41.
CLINICAL AND LABORATORY CHARACTERISTICS OF ABNORMAL PUBERTAL UTERINE BLEEDING
Kharkiv National Medical University, Kharkiv, Ukraine
One of the most common disorders of menstrual function during puberty is abnormal uterine bleeding puberty period. The main cause of uterine bleeding in adolescent girls is a defect in the interaction of the ovaries and the hypothalamic−pituitary area of the central nervous system. In order to identify the features of clinical and laboratory characteristics of abnormal uterine bleeding, 98 teenage girls aged 11 to 18 years were examined, 33 of them were hospitalized with relapses of bleeding.All patients were given anamnesis, ultrasound examination of pelvic organs, doppler examination, determination of hormonal profile (gonadotropic and sex hormones), biochemical examination with the study of parameters of the hemostasis system. As a result of the study, it was discovered that some of the etiological factors of abnormal uterine bleeding during puberty were changes in the physical and sexual development of patients, as well as hereditary predisposition to menstrual function disorders. An ultrasound examination showed an increase in ovarian volume with the development of follicular cysts, the presence of hyperplastic processes and increased blood flow in the endometrium. Established hormonal disorders indicate changes in the hypothalamic−pituitary−ovarian system. In teenage girls there are various−directional changes in the general condition of the hemostasis system, which are determined by the size of blood loss, the weight of the induced hemodynamic and metabolic disorders. In abnormal uterine bleeding puberty period, violations in gonadotropic ovarian function are observed, which leads to a change in the concentration of sex hormones. In adolescent girls with uterine bleeding, an increase in cortisol levels in serum is detected, which may indicate a high level of stress.
Key words: abnormal pubertal uterine bleeding, hemostasis system, hormonal disorders.