ARCHIVEOBSTETRICS AND GYNECOLOGY
TREATMENT OF EXO- AND ENDOCERVICITIS ASSOCIATED WITH NONSPECIFIC MIXED INFECTIONS OF THE LOWER GENITALS IN WOMEN OF REPRODUCTIVE AGE
Kharkiv Medical Academy of Postgraduate Education, Ukraine
A marked increase in infectious and inflammatory diseases in women under the age of social and reproductive activity has been noted. The frequency of dysbiosis of vaginal biotopes and cervical inflammatory diseases associated with nonspecific mixed infection, does not tend to decrease. Treatment of nonspecific exo− and endocervicitis involves the use of antibacterial, anti−inflammatory drugs predominantly of local action, in particular vaginal suppositories characterized by high bioavailability, absence of damage to saprophyte automicroflora, easy use, avoiding the risk of adverse reactions, prevention of background (precancerous) diseases of the cervix, that is of particular medical and social importance. A study was conducted in which the clinical efficacy of vaginal suppositories containing chloroquinaldol (quinofucine) was studied at exo− and endocervicites associated with nonspecific mixed infection of the lower genitalia in women of reproductive age. All patients underwent a comprehensive examination including clinical, gynecological, cytomorphological, bacteriological studies, simple and complex colpocervicoscopy. Treatment of patients with exo− and endocervicitis was performed by intravaginal application of chinofucin (1 suppository 2 times a day for 7−10 days). The results of the treatment showed that on the 7th day of treatment the patients secretion from the genital tract reduced, the phenomena of dyspareunia were absent, the level of leukocytes in the vaginal discharge and cervical canal reduced. By the 10th day, reduction in the number of epithelial cells was noted, lactobacillary microflora dominated in the microbial composition of the vaginal biotope, the purity of the vagina corresponded to grade 1−2. Thus, the use of vaginal suppositories of chinofucin (Lekhim, Ukraine) containing chlorquinaldol, in patients with nonspecific exo− and endocervicitis promotes effective eradication of pathogenic cocco−bacillary microflora without suppressing the saprophytic autoflora of the vaginal biotope, has a pronounced anti−inflammatory effect, promotes restoration of microbiocenosis, that allows the use of this medicine in infectious and inflammatory diseases of the vagina and cervix in women of reproductive age.
Key words: exocervicitis, endocervicitis, nonspecific infections, vaginal suppositories сhinofucin, clinical efficiency, women of reproductive age.