ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 23., Iss. 2, 2017, P. 41−44.
THE STATE OF HYPERPLASTIC ENDOMETRIUM DEPENDING ON ENZYMES ACTIVITY IN PERIMENOPAUSAL WOMEN
Kharkiv National Medical University, Ukraine
Proteolytic enzymes are one of the mechanisms for controlling the functions of organs and tissues, playing a regulatory role in the molecular mechanisms of biological processes, i.e. cell division, differentiation and morphogenesis. The family of matrix metalloproteinases is a group of related zinc−containing proteolytic enzymes (endopeptidases) destroying the basal membranes and extracellular matrix under physiological and pathological conditions. In gynecological practice, one of the most common diseases associated with restructuring and proliferation of the epithelial tissue is endometrial hyperplasia. The purpose of this study was to examine the state of the endometrium in perimenopausal period and match the degree of activity of matrix metalloproteinases and their tissue inhibitors at endometrial hyperplasia. Histological scrapings of the uterine cavity revealed morphological characteristics typical of a simple and complex form of endometrial hyperplasia. Multiple increase in the levels of expression of MMP−1 and MMP−9 and TIMP−1 expression and gene TIMP−2 was revealed, indicating significant disorders of the enzyme activity of the extracellular matrix. Determination of the concentration of matrix metalloproteinases (MMPs−1, MMPs−9) and their tissue inhibitors (TIMP−1, TIMP−2) in the endometrium can be used for predicting development of hyperplasia and diagnosis of the degree of the pathology with the purpose to develop the most effective treatment. The findings of this study can also promote quantitative risk assessment of occurrence of hyperplastic processes and predict their development before clinical manifestation.
Key words: endometrial hyperplasia, matrix metalloproteinases, tissue inhibitors, perimenopausal period.