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№3' 2016
OBSTETRICS AND GYNECOLOGYInternational Medical Journal, Vol. 22., Iss. 3, 2016, P. 29−31.
THE ROLE OF HEMOSTASIS IN THE PATHOGENESIS OF PLACENTAL DYSFUNCTION
Kharkiv National Medical University, Ukraine
Prevention of perinatal morbidity and mortality are one of the most urgent problems of modern obstetrics. Placental dysfunction (PD) is a leading cause of perinatal morbidity and mortality and one of the most common complications of pregnancy. Pregnant women with hemodynamic disorders of the fetoplacental system, who were divided into 3 groups depending on the degree of hemodynamic disorder, were investigated. The investigation showed that increase in the total activity of coagulation blood factors, thrombinemia markers, decreased anticoagulant and fibrinolytic activity of the blood suggest a form of compensated chronic disseminated intravascular coagulation (DIC) in pregnant women with disorders of the hemostatic system. These results allow us to conclude that coagulation disorders of homeostasis are important in the pathogenesis of placental dysfunction. This is one of the causes of hemodynamic disorders in placental system accompanied by the changes in the structure of the spiral arteries.
Key words: system of hemostasis, spiral artery, placental dysfunction.