ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 22., Iss. 3, 2016, P. 32−35.
THE STATE OF IMMUNE STATUS AND CYTOKINES AT IN VITRO FERTILIZATION IN WOMEN WITH THROMBOPHILIA
Kharkiv National Medical University, Ukraine
One of the trends in infertility treatment is the use of auxiliary reproductive technologies, including in vitro fertilization (IVF). Improvement of its effectiveness is related to the study of immune regulation of female reproductive function. Women with thrombophilia demonstrate a significant reduction in sensitivity of the receptor apparatus of the endometrium due to the large doses of drugs during IVF. To study the immunological status and cytokines during IVF, the patients with thrombophilia and infertility of tubal origin were investigated. Based on the obtained findings it was revealed that stimulation of superovulation in IVF programs in women with thrombophilia significantly effects the condition of the humoral immunity. The negative result of IVF consists in increased immunoreactivity and significant increase in the content of ІL−1α, ІL−8 and TNFα. The humoral immune system is originally activated in the women with pregnancies due to IVF programs, and in women with ineffective IVF programs, cellular link is activated. It can be assumed that stimulation of superovulation reduces IL−8 level women in group IVF+ and thus to a certain extent, controls the manifestations of the humoral immunity and hardly effects cellular immunity.
Key words: immunological status, in vitro fertilization, thrombophilia, tubal infertility.