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№1' 2014

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 20., Iss. 1, 2014, P. 44−50.

PREVENTION OF PERINATAL PATHOLOGIES IN PREGNANT WOMEN FOLLOWING AUXILIARY REPRODUCTIVE TECHNOLOGIES

¹Kharkiv National Medical University; ²Kharkiv Regional Clinical Perinatal Centre

Pregnancy resulting from auxiliary reproductive technologies develops in specific conditions, has a large number of perinatal complications, reduction of which is an important issue of obstetrics. New diagnostic capabilities allow to specify the etiology and work out new approaches to definition of pathogenetic mechanisms of perinatal complications, especially after auxiliary reproductive technologies. To specify the pathogenesis and work out effective methods of prevention of perinatal complications of pregnancy resulting form auxiliary reproductive technologies 120 women were investigated, of them 90 in whom pregnancy resulted from application of auxiliary reproductive technologies and 30 with spontaneous pregnancy. It was revealed that one of main mechanisms of perinatal complication development which are usually due to hemodynamic disorders in the system mother−placenta−fetus, is forming endothelial dysfunction. A complex of measures aimed at optimizing of pregnancy management after auxiliary reproductive technologies which allows improvement of the course of gestation period reduce the number of perinatal complications both in the mother and the fetus by means of normalizing the disorders in the regulation mechanisms of the endothelial system and immunological homeostasis, which is achieved by the use of ozone therapy and immunocorrection before implantation.

Key words: perinatal pathologies, reproductive technologies, endothelial dysfunction.