ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 20., Iss. 1, 2014, P. 51−55.
MODERN ASPECTS OF COMPLEX THERAPY TO BE RECURRENT PAPILLOMATOUS VIRAL INFECTION
1Kharkiv National Medical University; 2Kharkiv Regional Clinical Perinatal Centre
Papillomavirus infection is extraordinarily difficult for diagnosis and therapy and requires protracted examination and treatment. The relapses are observed in 20−30% of the patients. The most typical manifestations of the infection are pointed anogenital condylomas. As a natural substance indol−3−carbinol (I3C) is the only pathogenetic means for the disease treatment associated with papillomavirus infection, efficiency of Indol−F® including I3C was investigated in complex treatment of anogenital condylomas. The investigation was conducted on 120 women with pointed condylomas of external genital organs, caused by human papillomavirus infection. all patients were treated using cryodestruction of condylomas with liquid nitrogen in combination with immunotropic therapy. In 45% cases relapses occurred. The women with the disease relapses, depending on the clinical form of PVI were divided into 2 groups: group 1 (26 women) with clinically expressed course of the disease; group 2 (28 women) with symptom−free virus carrier state. Every group was divided into sub−groups, in one of which the patients were given complex therapy including combination of local destruction of condylomas (by the method of cryotherapy) and administration of antiviral and immunomodulatory agents. In the other sub−group Indol−F® was administered. The findings of the research show that the use of Indol−F® is a promising and necessary to solve the problem of dissemination and consequences of viral urogenital infections. Complex use of Indol−F® in combination with antiviral agents, immunomodulators and destructive therapy can guarantee recovery of the patients and absence of the disease relapses..
Key words: papillomatous viral infection, pointed condylomas, therapy.