International Medical Journal, Vol. 19., Iss. 2, 2013, P. 89−92.
MOLECULAR GENETIC CHARACTERISTICS OF SPORADIC GASTRIC CANCER
Kharkiv Medical Academy of Post−graduate Education, Kharkiv, Ukraine
Abstract. The results of chemoradiation treatment with the use cisplatin and 5−fluoruracil (5−FU) in patients with locally−advanced cancer of the stomach depending on microsatellite instability (MSI) of loci of BAT−25 and BAT−26 responsible for genes of postreplicative reparation of MSH2, MLH1 are presented. It is shown that 50% of patients with locally advanced cancer of the stomach have mutation phenotype with MSI on BAT−25; BAT−26 loci. Maximum therapeutic effect of x−ray therapy with modification with cisplatin was achieved in patients without MSI; and modification with 5−FU at MSI on BAT−25; BAT−26 loci. Toxic effects of chemoradiation therapy are not connected with genetic features of the tumor and are the result of action of cisplatin and 5−FU on the organs and systems of the organism of the tumor−carrier.
Key words: gastric cancer, microsatellite instability, chemoradiation therapy.