International Medical Journal, Vol. 19., Iss. 2, 2013, P. 93−99.
LABORATORY PARAMETERS AS PREDICTORS OF BLADDER TUMOR MALIGNANCY GRADE
National Cancer Centre of Belarus, Minsk, Republic of Belarus
Abstract. To evaluate the significance of laboratory indices for determining the malignancy grade, updated laboratory techniques (immunoenzyme, immunoturbidity method, spectrofluorometry, electron paramagnetic resonance spectrometry) were used to study tumor markers, growth factors, angiogenesis, intercellular adhesion, and endothelial damage, products of inflammation and oxidative modification of proteins and lipids in body fluids of 552 patients with nonmusculo−invasive urinary bladder cancer. Statistical analysis of the obtained findings allowed to distinguish of investigating 27 parameters of 8 indices of maximal correlation with the tumor grade. An algorithm for laboratory examination of urinary bladder cancer patients, which makes it possible to predict the tumor grade as early as in the preoperative period, is proposed. This enables the clinicians to assess adequately the risk of disease recurrence or progression and to use a differentiated treatment approach.
Key words: bladder cancer, laboratory findings, biological fluids.