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CURRENT ISSUE

№2' 2020

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 26., Iss. 2, 2020, P. 32−38.


DOI (https://doi.org/10.37436/2308-5274-2020-2-7)

RELATIONSHIP OF MATERNAL VITAMIN B12 STATUS IN PREGNANCY WITH PRETERM BIRTH AND MATERNAL HEALTH RISKS


Spasova V. L., Koleva L. I., Popova M. A., Petkova V. B., Dimitrov M. V.

Department of Medical Genetics, Faculty of medicine, Medical University of Sofia
Clinic of Operative Surgery, UMBALSM "Pirogov", Sofia
Second Gynecology clinic, University Hospital of Obstetrics and Gynecology "Maichin dom", Sofia
Department of Obstetrics and Gynecology, Medical University of Sofia
Faculty of Pharmacy, Medical University, Sofia, Bulgaria

Vitamin B12 is known to be vital for cell growth and population during pregnancy. This retrospective and prospective case−control study was aimed to disclose a health risk for pregnant women with vitamin B12 deficiency, as well as the one of the preterm birth. The main tasks set and performed in this research were as follows: to compare the obstetrics anamnesis between the women who gave birth on term and women who gave birth before term; to find the prevalence of vitamin B12 insufficiency in pregnancy; to determine its association with preterm birth and low birth weight; to examine its association with spontaneous abortions, and to investigate its relationship with obesity and hemoglobin levels in pregnant women. The conducted investigation involved 107 women who gave birth before the 37th week of gestation and 101 women who gave birth after the 37th week of gestation at the outpatient clinic of the University Hospital "Maichin Dom" in Bulgaria. Our study revealed a correlation between maternal vitamin B12 deficiency, overweight and low hemoglobin level. Our results showed no significant correlation between serum vitamin B12 level and the risk of preterm birth. However, we found an inverse association between vitamin B12 level and overweight before pregnancy and at the time of giving birth. As well there was confirmed the strong connection between meat consumption and vitamin B12 level. The paper emphasizes that the deficiency of the vitamin occurs most likely in the women with inadequate diets. Such a deficiency is actually confirmed to have serious health consequences for pregnant women and their offspring. Therefore further profound and numerous studies should be performed to properly assess the correlation between vitamin B12 and preterm birth, as well as to understand better the impact of vitamin B12 over pregnant women.

Key words: vitamin B12, preterm birth, pregnancy, overweight, hemoglobin.


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