International Medical Journal, Vol. 24., Iss. 2, 2018, P. 64−67.
LIPID METABOLISM FEATURES IN HIV-INFECTED PERSONS WITH CHRONIC HEPATITIS C AND IN PATIENTS WITH HIV/HCV CO-INFECTION
Kharkiv National Medical University, Ukraine
Worldwide hepatitis C virus and human immunodeficiency virus (HIV) are the causative agents of two of the most important and most common viral infections, causing significant morbidity and mortality. Acting synergically these two viruses accelerate liver damage progression. To assess the status of lipid metabolism indices in HIV−infected individuals, patients with hepatitis C and HIV/HCV co−infection, total cholesterol, triglycerides, high−density lipoproteins, low and very low density were determined in the blood serum; atherogenicity coefficient was calculated. Patients of all groups had a significant increase in serum levels of triglycerides, lipoproteins, low and very low density lipoproteins, reduction of high density lipoproteins. In patients with HIV/HCV co−infection a higher level of triglycerides was detected, as well presence of a moderate direct relationship between CD4+ cell level in the peripheral blood and the increase degree of a serum triglycerides as well as atherogenicity coefficient. This indicates a disorder of lipid profile in HIV−infected persons with chronic hepatitis C and patients with HIV/CHC co−infection, which necessitates their identification, recording and monitoring during the course of illness, including life−long administration of antitetroviral therapy.
Key words: HIV−infection, chronic hepatitis C, co−infection HIV/HCV, lipid metabolism.