ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 24., Iss. 1, 2018, P. 55−59.
COMPARATIVE ANALYSIS OF THE MORPHOLOGICAL AND HISTOCHEMICAL STATE OF THE ENDOMETRIUM AFTER OOCYTE ASPIRATION AT DIFFERENT LUTEAL PHASE SUPPORT SCHEMES
Kharkiv National Medical University, Ukraine
The main method of infertility treatment is currently in vitro fertilization (IVF). In order to improve the effectiveness of IVF cycles, special attention has been paid to investigation of the state of the endometrium. The final stage in the diagnosis of the state of the endometrium is its morphological study. The aim of the present work was to study the morphological and histochemical changes in the endometrium in the donors on the fifth day after oocyte collection under different schemes of luteal phase (LF) support. On the day of the puncture, LF support began. On the 5th day after oocyte collection, the endometrium obtained with the biopsy was taken for morphological and histochemical study. In group 1, the endometrium obtained in the natural ovarian−menstrual cycle was studied; in group 2, for support of LF, the patients received dydrogesterone orally 30 mg per day; in group 3 −− highly purified progesterone for subcutaneous administration in combination with intravaginal progesterone gel (90 mg). Based on the comparative analysis of the morphological and histochemical state of the endometrium, it can be concluded that the most expressed readiness of the endometrium for blastocyst implantation is noted in patients of group 3, in whom the luteal phase of the ovarian−menstrual cycle was supported by highly purified progesterone for subcutaneous administration in combination with the intravaginal form of progesterone in the form of a gel (90 mg).
Key words: endometrium, in vitro fertilization, luteal phase, progesterone.