International Medical Journal, Vol. 24., Iss. 1, 2018, P. 60−63.
PROTEIN AND CARBOHYDRATE METABOLISM DISORDERS IN PATIENTS WITH MALIGNANT TUMORS OF THE INTESTINE
S. P. Grygoriev Institute for Medical Radiology, NAMS of Ukraine, Kharkiv
Kharkiv National Medical University
Reginal Cancer Center, Kharkiv, Ukraine
Cancer patients are characterized by changes in the system of anabolism−catabolism with a sharp increase in the need for energy donors and plastic material, increase in real energy demand and parallel development of the pathological tolerance of the organism to «normal nutrients». To study the characteristics of protein and carbohydrate metabolism in primary patients with locally advanced colorectal cancer, a study of carbohydrate and protein metabolism was conducted in 108 primary patients. The state of protein metabolism was studied using unified methods. When this syndrome is formed, there is a marked predominance of catabolic processes. Thus, carbohydrate metabolism is characterized by activation of gluconeogenesis in the liver. In this case, the main substrates are their own amino acids (alanine, glycine), formed during the decay of own somatic and visceral proteins. Disorders of protein metabolism are manifested by a pronounced predominance of protein breakdown (mobilization of own amino acids from somatic and visceral proteins) over its synthesis. In this case, active synthesis of proteins of the «acute phase» predominates in the liver. As a result, concentration of visceral proteins (albumin, transferrin) decreases rapidly. However, the total protein content may even increase due to the fraction of globulins. Thus, the study of protein−carbohydrate metabolism both in primary cancer patients and at different stages of combined treatment is an urgent task, the solution of which can contribute to increasing the effectiveness of the main methods of antiblastoma treatment. As a result of all these changes, protein−energy deficiency progresses, which contributes to organ dysfunction and decrease in the effectiveness of complex therapy.
Key words: local colorectal cancer, protein metabolism, carbohydrate metabolism.