ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 22., Iss. 1, 2016, P. 48−51.
THE CONDITION OF IMMUNE FACTORS AND CYTOKINES AT PLACENTAL INSUFFICIENCY
Kharkiv National Medical University, Ukraine
The immune system plays a major role in maintaining normal biological relationship between the mother and fetus. The aim of the study was to examine the state of immunological factors and cytokines in pregnant women with placenta insufficiency (PIN). The study involved 162 pregnant women in the period of gestation 17−38 weeks, who were divided into 3 groups: group 1 −− 62 pregnant women with PIN against a background of extragenital pathology, group 2 −− 65 pregnant women with PIN against a background of obstetric pathology, group 3, control group −− 35 healthy women with uncomplicated gestational period. Autoantibodies to tissue factor, the content of immunoglobulins G, M and A in maternal and umbilical cord blood and the concentration of cytokines were determined. The study revealed that PIN disturbed the single integrated cellular−humoral system of protection, including immunity, hemostasis and nonspecific resistance of the mother and fetus. PIN is characterized by a fivefold increase in antibody production compared to the controls: blood concentration of IgM, IL−8, the indicators of mean cytochemical coefficient (MCC), increased concentration of IL−1? and TNF?. High levels of IL−1 ? in the cord blood at PIN reflect the degree of increased antigenic load, which leads to increased permeability of the blood brain barrier and may play a role in the pathogenesis of perinatal involvement of the central nervous system of the newborn.
Key words: placental insufficiency, cytokines, antibodies.