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№4' 2015
ANESTHESIOLOGYInternational Medical Journal, Vol. 21., Iss. 4, 2015, P. 78−83.
PATHOGENETIC ROLE OF INFUSION COMPONENT IN TRAUMATIC DISEASE IN GERIATRIC PATIENTS
Kharkiv National Medical University, Ukraine
The aim of the work was to increase the effectiveness of treatment of critical condition in geriatric patients and improve their quality of life after discharge from the hospital on the example of traumatic disease by means of differentiated approach to the choice of the complex intensive therapy. A long complex clinical, instrumental and laboratory dynamic study of hemodynamic, biochemical parameters, as well as markers of endothelial dysfunction and apoptosis in was done in 92 geriatric patients with multiple injuries the time of admission and within the period from the 1st day to 1 year from the date of injury. The effectiveness of the proposed complex intensive therapy was assessed in a prospective, randomized, open comparative clinical study in 48 patients in the period 2011−2015. Given the lack of significant differences in the statistical analysis of hemodynamic parameters in patients of groups 1,2 and 3, administration of GEK 200/0.5 6 % from the date of admission makes it a drug of choice in geriatric patients in intensive care, providing effective endothelioprotection. Administration of monoinfusion with GEK 200/0.5 6 % reduced the number of complications in the late period of traumatic disease in elderly and old patients. Endothelial dysfunction in geriatric patients with polytrauma lasts a year or more from the date of injury; are natural and unidirectional, have periods of recession and recovery. The degree of damage, the consistency of compensatory possibilities and the ability to restore endothelial function in geriatric patients with multiple injuries depends on the type of infusion component in the complex intensive therapy.
Key words: geriatric patients, traumatic disease, pathogenesis, intensive therapy.