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№4' 2015
ANESTHESIOLOGYInternational Medical Journal, Vol. 21., Iss. 4, 2015, P. 84−87.
CORRECTION OF POSTOPERATIVE COGNITIVE DYSFUNCTION IN GERIATRIC PATIENTS AFTER SURGERY
Kharkiv National Medical University, Ukraine
The aim of the work was correction of postoperative cognitive dysfunction in geriatric patients after surgery. The study involved 96 elderly patients with surgical abdominal pathology undergoing urgent surgery under general anesthesia by thiopental sodium with mechanical ventilation. Patients in group 1 were treated according to the protocol, group 2 −− adding Tiocetam, group 3 −− Cytoflavin. After surgery, patients were transferred to the intensive care unit. The study was conducted in 6 stages: prior to surgery and on the 1st, 2nd, 5th, 12th and 30th day after it. Geriatric patients with acute surgical abdominal pathology had certain cognitive dysfunction, primarily determined by age in the preoperative period. Postoperatively, the state of cognitive functions was significantly affected by the duration of surgery and in the first two days − the intensity of stress reactions. The return of cognitive functions to baseline state occurred only 30 days after surgery. Tiocetam and Cytoflavin promote earlier restoration of cognitive functions, on day 5 after surgery; later the state of cognitive functions improves and on day 30 day significantly exceeds the initial level, with more pronounced effects of Cytoflavin due to the ability of these drugs to reduce the influence of stress reactions caused by duration and intensity of the operation on the state of cognitive functions.
Key words: geriatric patients, postoperative period, cognitive dysfunction.