ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 21., Iss. 2, 2015, P. 34−38.
THE EFFECT OF INTRAUTERINE FETAL INFECTION ON CALCIUM AND MAGNESIUM EXCHANGE IN PREGNANT WITH UROGENITAL INFECTION
Kharkiv National Medical University, Ukraine
Mineral insufficiency is currently considered one of obstetric and perinatal problems. Balanced supply of both mother and fetus with necessary amount of biogenic elements is essential for a normal course of pregnancy. Calcium and magnesium belong to mineral substances of paramount importance. Their contents in mother's body can be influenced by various pathologic factors, including infectious agents. The aim of the study was to determine a possible impact of intrauterine infection on the state of calcium and magnesium exchange in pregnant patients with urogenital infections of various etiology and their newborns. To achieve this aim the authors assessed blood serum of 254 pregnant patients with viral, bacterial and viral−bacterial infections and umbilical blood of newborns to determine the contents of calcium and magnesium by spectrophotometry with the use of diagnostic kits. The control group included 50 women with physiological course of pregnancy. The presence of any of the above mentioned infections was found to induce the development of moderate, but significant in comparison to the control group, hypocalcemia. Besides, intrauterine infection not only induced hypocalcemia in mother, but also reduced the intake of calcium by the fetus regardless of the type of infectious agent. Central trend of serum magnesium level alteration in the groups under study was almost similar to calcium level alterations. The presence of hypomagnesemia in mother to a certain extent also resulted in a reduction of magnesium intake by the fetus, as evidenced by its decreased amount in umbilical blood. It can be concluded that this group of pregnant patients with intrauterine fetal infection requires not only administration of the corresponding antiviral and antibacterial therapy but also mineral status correction.
Key words: pregnancy, urogenital infection, intrauterine infection of the fetus, calcium and magnesium exchange.