ARCHIVE
№2' 2015
CLINICAL PHARMACOLOGYInternational Medical Journal, Vol. 21., Iss. 2, 2015, P. 79−85.
PRESSING ISSUES OF ANGIOPROTECTOR ADMINISTRATION
N. I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
Modern classification of angiotropic drugs from the group of targeted, affecting target cells and organs is presented. The effectiveness and safety of pharmacotherapy with angioprotectors is influenced by two main factors: the chemical structure of the active substance (selectivity of angioproteguoe effect) and the concentration of the active substance in the vicinity of the target (value of angioproteguoe effect). Pharmacokinetics and pharmacodynamics of these drugs are described in sequential stages. The antioxidant and antiradical properties of the active substances of natural flavonoids comprising the angioprotectors (particularly quercetin and its metabolites) are discussed. Venotonic action of flavonoids in the treatment of chronic venous insufficiency is emphasized. Particular attention is paid to safety of pharmacotherapy with systemic phleboprotectors, because the literature reports prooxidant action of flavonoids, which is expressed in the damage of biological structures, general decline in the viability of cells. This stresses the necessity of further research in order to expand the clinical use of quercetin and its derivatives.
Key words: angioprotectors, bioflavonoids, quercetin, water−soluble fraction of flavonoids, efficacy and safety of therapy.