PROGNOSTIC SIGNIFICANCE OF MORPHOLOGICAL PARAMETERS OF RENAL CELL CARCINOMA WITH INTRAVENOUS INVASION
Kharkiv National Medical University, Ukraine
V. I. Shapoval Regional Center of Urology and Nephrology, Kharkiv, Ukraine
One of important problems of modern oncology is search for the signs and properties of kidney tumors, based on which one could predict the course of the disease and determine the appropriate treatment. In addition to the clinical stage, their essential characteristics are histological variant, the degree of differentiation and biological aggressiveness. Owing to advances in molecular biology, new key points of carcinogenesis and tumor cell parameters have become clear. Thus, the key role of interaction of tumor cells and stroma during tumor progression and metastasis is played by activation of matrix metalloproteinases. Investigation of MMP−9, type IV collagen, a marker of endothelial cells CD 31 and vascular endothelial growth factor VEGF in renal cell carcinoma can aid in establishing the characteristics of their expression in tumor thrombi, thus simultaneous analysis of the content of these antibodies in the tissue of the patients is important. One study have evaluated the role of micro−RNAs in development of tumor thrombi at clear−cell renal carcinoma analyzing the expression of miR−200c, miR−210, miR−126, miR−221, let−7b, miR−21, miR−143, miR−141. Their expression profile allowed the authors to create a classification system. The analysis of morphological parameters of renal cell carcinoma with macroscopic intravenous invasion is still one of the most important directions of oncourology development. This information will allow distinguishing the most important prognostic factors for patients with renal cell cancer, especially evaluation of the pathogenesis of intravenous tumor invasion and choice of the best technique for adjuvant therapy.
Key words: renal cell carcinoma, intravenous invasion, tumor thrombus, prognostic factors.