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№4' 2013

INFECTIOUS DISEASES

International Medical Journal, Vol. 19., Iss. 4, 2013, P. 73−77.

COMPARISON OF CLINICAL EFFECT OF VARIOUS KINDS OF COMPLEX THERAPY FOR CHRONIC ACQUIRED TOXOPLASMOSIS IN THE STAGE OF ACCELERATION

Kharkiv Medical Academy of Postgraduate Education

The clinical effect of different types of complex therapy for chronic acquired toxoplasmosis was compared based on the clinical laboratory and electrophysiological data of the state of the immune system of the patients. The efficacy of complex treatment of 143 patients was determined in three groups: group 1 (n = 45) was treated with antiprotozoal therapy with a combination of pyrimethamine+sulphadoxine; group 2 (n = 48) was administered combination therapy with an antiprotozoal drug and specific anti−toxoplasmosis immunoglobulin; group 3 (n = 50) was treated with specific immunoglobulin against human Toxoplasma gondii. Tolerability and efficacy of the drugs was assessed with the use of complex (clinical, laboratory and immune) examination of the patients before the preparation administration, 1 month, and 5 − 6 months after the beginning of the treatment. The best clinical immunological effect at treatment of the patients with chronic acquired toxoplasmosis on the stage of exacerbation was achieved at treatment with combination therapy. Therapy with specific immunoglobulin against human Toxoplasma gondii took the interim position, and therapy with pyrimethamine+sulphadoxine appeared to be least effective. The obtained findings should be considered when treating this group of patients.

Key words: chronic acquired toxoplasmosis, antiprotozoal therapy, immunotherapy, immunoglobulin, human Toxoplasma gondii, combination therapy, T− and B−immunity.