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№3' 2013
CARDIOLOGYInternational Medical Journal, Vol. 19., Iss. 3, 2013, P. 41−45.
THE INFLUENCE OF ANGIOTENSIN-CONVERTING ENZYME GENE POLYMORPHISM ON THE INDICES OF TOLERANCE TO PHYSICAL LOAD IN PATIENTS WITH CORONARY ARTERY DISEASES
Kharkiv Medical Academy of Postgraduate Education
Abstract. The purpose of the study was to investigate the relation of insertion−deletion (I/D) polymorphism of the angiotensin−converting enzyme (ACE) gene with the parameters determining exercise tolerance (ET) in patients with coronary artery disease (IHD). The study involved 152 male patients with CAD with hemodynamically significant (according to selective coronary angioventriculography) stenoses of the coronary arteries. The examination of patients included a load test by modified Bruce protocol. The study of the ACE gene I/D polymorphism in the buccal epithelium was performed by polymerase chain reaction. It was established that in the group of patients with CAD low tolerance to physical exercise is independently associated with diffuse type of coronary artery damage, obesity, smoking and the presence of D allele of ACE gene insertion−deletion polymorphism.
Key words: angiotensin−converting enzyme gene polymorphism, coronary artery disease.