International Medical Journal, Vol. 19., Iss. 3, 2013, P. 46−49.
ASSESSMENT OF MYOCARDIUM STRUCTURAL FUNCTIONAL STATE AND DIASTOLIC FUNCTION IN PATIENTS WITH STABLE ANGINA AND ACCOMPANYING OBESITY
Kharkiv National Medical University
Abstract. The purpose of the research was to study progression of cardiohemodynamics indices and their correlation with adipocytokines and neopterin in patients with stable angina and obesity. Adipokines and neopterin levels were assessed by immunoenzyme methods using immunoenzyme analyzer "LabLine−90" (Austria). Echo−CG and Doppler echocardiographic investigation of structural and functional state of myocardium was carried out using "Radmir" unit in �−mode and two−dimensional mode in standard echocardiographic positions. The research demonstrated that obesity played a major role in the development of structural and functional changes in myocardium of the left ventricle in patients with stable angina, contributed to the development of left ventricular myocardial hypertrophy on the account of increase in left ventricular posterior wall thickness by 6.3% and left ventricular myocardium mass by 29.6% in this cohort of patients; Patients with stable angina and associated obesity were found to have evident diastolic dysfunction by the type of relaxation, which was observed in 57% of patients.
Key words: stable angina, obesity, fat tissue hormones.