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№3' 2013

CARDIOLOGY

International Medical Journal, Vol. 19., Iss. 3, 2013, P. 33−40.


BLOCKERS OF RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN TREATMENT OF ARTERIAL HYPERTENSION: CLASSICS VS. MODERN


Kanorsky S. G.

Kuban State Medical University, Krasnodar, Russian Federation

Abstract. The current literature on the impact of renin−angiotensin system blockers on the prognosis in patients with cardiovascular disease was analyzed. It is shown that according to new randomized trials and meta−analysis, angiotensin II receptor blockers and direct renin inhibitor aliskiren do not reduce the risk of cardiovascular complications and mortality in a wide range of clinical conditions, besides may worsen renal outcomes. Angiotensin−converting enzyme inhibitors, in particular perindopril (10 mg) and its combination with indapamide (2.5 mg) capable of reducing the mortality of patients with hypertension should be preferred to angiotensin receptor blockers II.

Key words: arterial hypertension, angiotensin−converting enzyme inhibitors, angiotensin II receptor blo−ckers, Aliskiren.


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