Previous Next

CURRENT ISSUE

№1' 2022

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 28., Iss. 1, 2022, P. 35−38.

DOI (https://doi.org/10.37436/2308-5274-2022-1-7)

STATE OF BLOOD COAGULATION SYSTEM IN PREGNANT WOMEN ON THE BACKGROUND OF THROMBOPHILIA AND BURDENED OBSTETRIC HISTORY

Kharkiv National Medical University, Ukraine

In most cases, the normal pregnancy course is disrupted as a result of complications, the development of which is responsible for the abnormal vascular network of the placenta and hemostasis due to thromboembolic disorders. The state of blood coagulation system in pregnant women on the background of thrombophilia and burdened obstetric history was analyzed. There was a slight predominance of prothrombin levels in pregnant women in the absence of thrombophilia compared to pregnant women with thrombophilia. An increased levels of thromboplastin time, international normalized ratio and prothrombin time during pregnancy on the background of thrombophilia in comparison with its course without it was determined. The same levels of fibrin−monomeric complexes were intentionally noted during pregnancy both with and without thrombophilia. The predominance of thrombin time levels in pregnant women with thrombophilia was likely to be found in contrast to a strong prevalence of fibrinogen levels in women without thrombophilia. The predominance of homocysteine levels among pregnant women with thrombophilia compared to those without thrombophilia was established, as well as the probable significant predominance of D−dimer in thrombophilia compared to the control. Intentionally lower levels of prothrombin production were observed in thrombophilia and pregnancy burden compared to unburdened pregnancy. The predominance of thromboplastin time, international normalized ratio and prothrombin time in aggravated current pregnancy compared to its normal course was intentionally stated; as well as thrombin time and homocysteine levels compared to the current course of pregnancy. Some predominance of levels of fibrin−monomer complexes, fibrinogen and D−dimer in women with a normal current pregnancy on the background of thrombophilia compared with its complicated course has been recorded.

Key words: blood coagulation system, pregnant women, burdened obstetric history, thrombophilia.

REFERENCES

1. Adverse pregnancy outcomes and inherited thrombophilia / D. Dłuski, R. Mierzyński, E. Poniedziałek−Czajkowska, B. Leszczyńska−Gorzelak. J. Perinat. Med. 2018. № 46 (4). P. 411−417. doi: 10.1515/jpm−2017−0059

2. Pabinger I. Thrombophilia and its impact on pregnancy. Thrombosis Research. 2009. № 123 (3). P. S16−S21. doi: https://doi.org/10.1016/S0049−3848(09)70128−8

3. Thromboprophylaxis in pregnant women with thrombophilia and a history of thrombosis / S. Akinshina et al. J. Perinat Med. 2018. № 46 (8). P. 893−899. doi: 10.1515/jpm−2017−0329

4. Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta−analysis / F. N. Croles et al. BMJ. 2017. № 359. P. j4452. doi: 10.1136/bmj.j4452

5. Comparison of 2 approaches in management of pregnant women with inherited trombophilias: Prospective analytical cohort study / W. Yang et al. Medicine (Baltimore). 2019. № 98 (34). P. e16883. doi: 10.1097/MD.0000000000016883

6. Lіnnіkov V., Lіnnіkov S. Trombofіlіya yak klyuchova lanka patogenezu uskladnen' v akusherstvі ta gіnekologії. Nauka і osvіta. 2019. № 3. S. 31−36. doi: 10.24195/2414−4665−2019−3−5

7. Therapeutic Implications of Inherited Thrombophilia in Pregnancy / L. F. Trasca et al. Am. J. Ther. 2019. № 26 (3). P. e364−e374. doi: 10.1097/MJT.0000000000000985

8. Can thrombophilia worsen maternal and perinatal outcomes in cases of severe preeclampsia? / F. S. Baptista et al. Pregnancy Hypertens. 2018. № 11. P. 81−86. doi: 10.1016/j.preghy.2017.12.012

9. Uterine Radial Artery Resistance Index Predicts Reproductive Outcome in Women with Recurrent Pregnancy Losses and Thrombophilia / S. H. Bao et al. Biomed. Res. Int. 2019. № 35. P. 78−80. doi: 10.1155/2019/8787010

10. The Prevalence of Thrombophilia in Women with Recurrent Fetal Loss and Outcome of Anticoagulation Therapy for the Prevention of Miscarriages / R. Nahas, W. Saliba, A. Elias, M. Elias. Clin. Appl. Thromb. Hemost. 2018. № 24 (1). P. 122−128. doi: 10.1177/1076029616675967

11. Guidance for the treatment and prevention of obstetric−associated venous thromboembolism / S. M. Bates et al. J. Thromb. Thrombolysis. 2016. № 41 (1). P. 92−128. doi: 10.1007/s11239−015−1309−0

12. 'To test or not to test', the arguments for and against thrombophilia testing in obstetrics / L. Ormesher, L. E. Simcox, C. Tower, I. A. Greer. Obstetric medicine. 2017. № 10 (2). P. 61−66. doi: 10.1177/1753495X17695696

13. Scheres L. J. J., Bistervels I. M., Middeldorp S. Everything the clinician needs to know about evidence−based anticoagulation in pregnancy. Blood Rev. 2019. № 33. P. 82−97. doi: 10.1016/j.blre.2018.08.001

14. Mel'nik Yu. M., Zhuk S. І., Atamanchuk І. M. Endotelіal'na disfunktsіya yak marker platsentarnoї nedostatnostі. Zdorov'e zhenshchiny. 2016. № 9 (115). S. 47−51.

15. Zhuk S. І., Us І. V., Atamanchuk І. M. Klіnіko−laboratorna kharakteristika vagіtnikh іz zagrozoyu peredchasnikh pologіv na fonі trombofіlіchnikh stanіv. Biomedical and biosocial anthropology. 2015. № 25. S. 141−145.