CURRENT ISSUEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 28., Iss. 1, 2022, P. 35−38.
STATE OF BLOOD COAGULATION SYSTEM IN PREGNANT WOMEN ON THE BACKGROUND OF THROMBOPHILIA AND BURDENED OBSTETRIC HISTORY
Kharkiv National Medical University, Ukraine
In most cases, the normal pregnancy course is disrupted as a result of complications, the development of which is responsible for the abnormal vascular network of the placenta and hemostasis due to thromboembolic disorders. The state of blood coagulation system in pregnant women on the background of thrombophilia and burdened obstetric history was analyzed. There was a slight predominance of prothrombin levels in pregnant women in the absence of thrombophilia compared to pregnant women with thrombophilia. An increased levels of thromboplastin time, international normalized ratio and prothrombin time during pregnancy on the background of thrombophilia in comparison with its course without it was determined. The same levels of fibrin−monomeric complexes were intentionally noted during pregnancy both with and without thrombophilia. The predominance of thrombin time levels in pregnant women with thrombophilia was likely to be found in contrast to a strong prevalence of fibrinogen levels in women without thrombophilia. The predominance of homocysteine levels among pregnant women with thrombophilia compared to those without thrombophilia was established, as well as the probable significant predominance of D−dimer in thrombophilia compared to the control. Intentionally lower levels of prothrombin production were observed in thrombophilia and pregnancy burden compared to unburdened pregnancy. The predominance of thromboplastin time, international normalized ratio and prothrombin time in aggravated current pregnancy compared to its normal course was intentionally stated; as well as thrombin time and homocysteine levels compared to the current course of pregnancy. Some predominance of levels of fibrin−monomer complexes, fibrinogen and D−dimer in women with a normal current pregnancy on the background of thrombophilia compared with its complicated course has been recorded.
Key words: blood coagulation system, pregnant women, burdened obstetric history, thrombophilia.
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