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№4' 2021

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 27., Iss. 4, 2021, P. 32−35.

DOI (https://doi.org/10.37436/2308-5274-2021-4-6)

ANTIOXIDANT PROTECTION OF PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS DEPENDING ON ITS SPREAD DEGREE

Kharkiv National Medical University, Ukraine

External genital endometriosis is one of the most common gynecological proliferative diseases. The disease development is based on molecular and genetic disorders that occur in women and are the result of the cell response to oxidative stress. In endometriosis the polymorphism of genes of detoxification systems, depletion of antioxidant defense mechanisms due to hormonal imbalance and activity of pro−inflammatory processes are called the causes of oxidative stress. Currently, much attention is paid to aspects of the immune system and local peritoneal factors. To develop diagnostic criteria for the stages of external genital endometriosis by determining the activity of enzymes of the antioxidant system and catalase in serum and peritoneal fluid, a study was performed in 86 patients. The research results showed that in external genital endometriosis of stages I−II in the serum of women the catalase activity increased, and that of superoxide dismutase remained at the physiological level. Determination of the studied enzymes in peritoneal fluid indicates that their parameters correspond to the control values in women without endometriosis. Thus, the study showed that the patients experience multidirectional changes in antioxidant system, which are manifested in increased catalase activity at the systemic level at the disease stages I−II and local one at stages III−IV. At the same time, the activity of superoxide dismutases at all stages of the disease in both serum and peritoneal fluid is normal. The state of the antioxidant system is concluded to depend on the peculiarities of micronutrient metabolism. Further study and correction of its possible disorders may positively affect in preventing and treatment of external genital endometriosis in women.

Key words: external genital endometriosis, antioxidant system, diagnostics.

REFERENCES

1. Endometrіoz: dosyagnennya ta pitannya v svіtovikh doslіdzhennyakh / S. V. Khmіl', І. Ya. Pіdgaina, І. І. Kulik, N. D. Koblosh // Vіsn. sotsіal'noї gіgієni ta organіzatsії okhoroni zdorov'ya Ukraїni. 2019. № 4 (82). S. 85−93. doi: https://doi.org/10.11603/1681−2786.2019.4.10953

2. Medvedєv M. V., Pokrovenko D. A. Suchasnii poglyad na etіologіyu, patogenez ta mozhlivostі dіagnostiki zovnіshn'ogo genіtal'nogo endometrіozu (oglyad lіteraturi) // Medichnі perspektivi. 2019. T. 24, № 1. S. 21−30.

3. Goncharenko G. Yu. Klіnіko−morfologіchnii analіz genіtal'nogo endometrіozu // Dosyagnennya bіologії ta meditsini. 2016. № 1 (27). S. 57−60.

4. Marchenko L. A., Il'ina L. M. Sovremennyi vzglyad na otdel'nye aspekty patogeneza endometrioza (obzor literatury) // Problemy reproduktsii. 2011. S. 20−25.

5. Gudkov G. V., Khanferyan R. A. Aktivnost' peritoneal'nykh fagotsitov i perekisnoe okislenie lipidov v peritoneal'noi zhidkosti u bol'nykh naruzhnym genital'nym endometriozom // Vestn. munitsipal'nogo zdravookhraneniya. 2009. № 3 (1).

6. Ermolova N. V. Patogeneticheskaya rol' endotelial'nykh faktorov i polovykh gormonov v formirovanii naruzhnogo genital'nogo endometrioza // Rossiiskii vestn. akushera−ginekologa. 2008. № 3. S. 29−32.

7. Postolenko V. Yu. Gormonal'no−іmunologіchnі osoblivostі endometrіozu matki u zhіnok z patologієyu shchitopodіbnoї zalozi ta bezplіddyam // Ukraїns'kii zhurn. meditsini, bіologії ta sportu. 2018. № 5 (14). S. 154−161.

8. Analiz ekspressii genov v monotsitakh perifericheskoi krovi pri endometrioze: vyyavlenye izmeneniya pri neginekologicheskikh khronicheskikh vospalitel'nykh zabolevaniyakh / D. Dasentelini i dr. // Hum. Reprod. 2011. Vol. 26, № 11. R. 3109−3117.

9. Reevaluating response and failure of medical treatment of endometriosis: a systematic review / C. M. Becker, W. T. Gattrell, K. Gude, S. S. Singh // Fertility and Sterility. 2017. Vol. 108, № 1. P. 125−136. doi: https://doi.org/10.1016/j.fertnstert.2017.05.004

10. Mediko−sotsial'nye aspekty endometrioza / M. M. Sonova i dr. // Problemy reproduktsii: materialy V Mezhdunar. kongr. po reproduktivnoi meditsine. 2011. Spets. vypusk. S. 153−154.

11. New developments in the medical treatment of endometriosis / M. A. Bedaiwy, S. Alfaraj, P. Yong, R. Casper // Fertility and Sterility. 2017. Vol. 107, № 3. P. 555−565. doi: https://doi.org/10.1016/j.fertnstert.2016.12.025

12. Gormonal'nii status khvorikh іz zovnіshnіm genіtal'nim endometrіozom u poєdnannі z gіpotireozom / B. M. Lisenko ta іn. // Klіnіchna ta profіlaktichna meditsina. 2019. T. 2, № 8. S. 58−62.

13. Retrospektivnii analіz reproduktivnoї funktsії zhіnok z genіtal'nim endometrіozom ta patologієyu shchitopodіbnoї zalozi / V. Yu. Postolenko, D. Є. Barkovs'kii, N. M. Pasієshvіlі, V. V. Lazurenko // Vіsn. mors'koї meditsini. 2018. № 1 (79). S. 17−22.

14. Tanbo T., Fedorcsak P. Endometriosis−associated infertility: aspects of pathophysiological mechanisms and treatment options // Acta Obstetricia et Gynecologica Scandinavica. 2017. Vol. 96. P. 659−667. doi: https://doi.org/10.1111/aogs.13082

15. Morphological features of uterine polyps in females of reproductive age / N. Y. Gorban, T. D. Zadorozhna, I. B. Vovk, I. V. Zhulkevych // Vіsn. naukovikh doslіdzhen'. 2019. № 2. S. 47−52. doi: https://doi.org/10.11603/2415−8798.2019.2.10267

16. Rebrova, O. Yu. Statisticheskii analiz meditsinskikh dannykh. M., 2003. 306 s.

17. Kachalina T. S., Semerikov M. V., Strongina L. P. Sovremennye predstavleniya o patogeneze naruzhnogo genital'nogo endometrioza // Sovremennye tekhnologii v meditsine. 2011. № 1. S. 117−122.

18. Sostoyanie perekisnogo okisleniya lipidov i antioksidantnoi sistemy u zhenshchin s besplodiem, obuslovlennym naruzhnym genital'nym endometriozom ili khronicheskim sal'pingitom / A. V. Volkova i dr. // Problemy reproduktsii: mater. V Mezhdunar. kongr. po reproduktivnoi meditsine. 2011. Spets. vyp. S. 98−99.