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№4' 2021

SURGERY

International Medical Journal, Vol. 27., Iss. 4, 2021, P. 18−23.


DOI (https://doi.org/10.37436/2308-5274-2021-4-3)

MODERN METHODS OF SURGICAL TREATMENT AND POST-SURGERY ANALGESIA IN PATIENTS WITH ESOPHAGEAL DISEASES


Usenko O. Yu., Sidyuk A. V., Klimas A. S., Sidyuk O. E., Savenko G. Yu., Teslia O. T.

SI "O. O. Shalimov National Institute of Surgery and Transplantology, National Academy of Medical Sciences of Ukraine", Kyiv, Ukraine

Esophageal cancer remains one of the most common cancers with a high mortality rate worldwide. A certain problem when treating the esophageal cancer is the highly traumatic surgery, a significant number of post−surgery complications from esophagogastroanastomosis and severe postoperative pain. Therefore, there is a need for new developments and techniques for the formation of esophagogastroanastomosis to minimize post−surgery complications. To reduce the number of postoperative anastomotic complications and improve the pain control in patients after esophageal resection, a study was conducted that included 60 patients with esophageal cancer and cardioesophageal transition. We compared two methods of esophagogastroanastomosis formation: intussusception mechanical and circular mechanical, as well as those of postoperative anesthesia, namely, a combination of thoracic paravertebral blockade and thoracic epidural anesthesia using only thoracic epidural anesthesia. Due to our findings the effectiveness of the proposed intussusception mechanical anastomosis was proven, which allowed to significantly reduce the frequency of endoscopically detected reflux esophagitis by 1.5 times at the end of the one year follow−up observation. It is established that anesthesiological support of postoperative anesthesia during surgery for malignant diseases of the esophagus using combined postoperative analgesia (thoracic paravertebral blockade and thoracic epidural anesthesia) reduces the endocrine−metabolic response in men, generally makes it possible to prevent the development of post−surgery complications.

Key words: esophageal cancer, gastroenteroanastomosis, thoracic epidural block, thoracic paravertebral anesthesia, cardioesophageal junction cancer.


REFERENCES


1. Tkach A. A. Suchasnii stan problemi lіkuvannya raku stravokhodu, prognoz zakhvoryuvannya ta otsіnka yakostі zhittya patsієntіv / Biomedical and biosocial anthropology. 2014. № 23. S. 263−269.

2. The European Organization for Research and Treatment of Cancer QLQ−C30: a quality−of−life instrument for use in international clinical trials in oncology / N. K. Aaronson et al. // J. Natl. Cancer Inst. 1993. № 85 (5). R. 365−376.

3. Ajani J. A., Barthel J. S., Bentrem D. J. Esophageal and esophagogastric junction cancers / J. Natl. Compr. Canc. Netw. 2011. № 9 (8). R. 830−887. doi: https://doi.org/10.6004/jnccn.2011.0072

4. Hospital volume and surgical mortality in the United States / J. D. Birkmeyer et al. // N. Engl. J. Med. 2002. Vol. 346 (15). P. 1128−1137. doi: 10.1056/NEJMsa012337

5. Djärv T., Lagergren P. Quality of life after esophagectomy for cancer // Expert Review of Gastroenterology & Hepatology. 2012. Vol. 6 (1). P. 115−122. doi: 10.1586/egh.11.91

6. Health−related quality of life among patients cured by surgery for esophageal cancer / P. Lagergren et al. // Cancer. 2007. Vol. 110 (3). P. 686−693. doi: 10.1002/cncr.22833

7. Minimally invasive intrathoracic anastomosis after Ivor Lewis esophagectomy for cancer: a review of transoral or transthoracic use of staplers / K. W. Maas et al. // Surg. Endosc. 2012. Vol. 26 (7). P. 1795−1802. doi: 10.1007/s00464−012−2149−z

8. Single−dose, bilateral paravertebral block plus intravenous sufentanil analgesia in patients with esophageal cancer undergoing combined thoracoscopiclaparoscopic esophagectomy: a safe and effective alternative / W. Zhang et al. // J. Cardiothorac. Vasc. Anesth. 2014. Vol. 28 (4). P. 966−972. doi: https://doi.org/10.1053/j.jvca.2013.12.007

9. Law S. Y. The Art and Science of Esophageal Anastomosis / S. Y. Law // Innovation in Esophageal Surgery. Sringler; 2012. P. 95−102. doi: 10.1007/978−88−470−2469−4_12

10. Lewis I. The surgical treatment of carcinoma of the oesophagus: with special reference to a new operation for growths of the middle third // Br. J. Surg. 1946. Vol. 34. P. 18−31. doi: 10.1002/bjs.18003413304

11. Usenko O. Yu., Sidyuk A. V., Klіmas A. S. Sposіb vikonannya ezofagektomії: pat. 107235. Ukraїna. № u201600001; zayavl. 04.01.2016; opubl. 25.05.2016, Byul. № 10.

12. Usenko O. Yu., Sidyuk A. V., Mazur A. P., Sidyuk O. Є. Sposіb znebolennya khvorogo pіslya ezofagektomії: pat. № 116693. Ukraїna. № u 201700153; zayavl. 04.01.2017; opubl. 25.05.2017, Byul. № 10.

13. Posіbnik z bіostatistiki. Analіz rezul'tatіv medichnikh doslіdzhen' u paketі EZR (R−statistics): navch. posіb. / V. G. Gur'yanov ta іn. K.: Vіstka, 2018. 208 s.

14. Cervical or thoracic anastomosis after esophagectomy for cancer: systematic review and meta−analysis / S. S. Biere, K. W. Maas, M. A. Cuesta, D. L. van der Peet // Dig. Surg. 2011. № 28 (1). R. 29−35. doi: 10.1159/000322014

15. Clinical and psychometric validation of a questionnaire module, the EORTC QLQ−OG25, to assess health−related quality of life in patients with cancer of the oesophagus, the oesophago−gastric junction and the stomach / P. Lagergren et al. // Eur. J. Cancer. 2007. № 43 (14). R. 2066−2073. doi: 10.1016/j.ejca.2007.07.005

16. Development of consensus guidelines for the histologic recognition of microscopic esophagitis in patients with gastroesophageal reflux disease: the Esohisto project / R. Fiocca et al. // Hum. Pathol. 2010. № 41 (2). R. 223−231. doi: 10.1016/j.humpath.2009.07.016

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