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№3' 2021

OBSTETRICS AND GYNECOLOGY

International Medical Journal, Vol. 27., Iss. 3, 2021, P. 33−36.

DOI (https://doi.org/10.37436/2308-5274-2021-3-7)

POSSIBILITIES OF USING COMBINED SECOND GENERATION ORAL CONTRACEPTIVES IN OVERWEIGHT WOMEN

Zaporizhzhia State Medical University, Ukraine

Many gynecological studies are devoted to the problem of overweight in women. One of the topical issues is the prevention of unwanted pregnancies in this category of patients. A study was conducted to evaluate and compare the safety and effectiveness of different types of modern hormonal contraception in 60 young overweight women. All the patients were divided into two groups: those who used the second−generation combined oral contraceptives (30 µg ethinyl estradiol and 150 µg levonorgestrel) and those who took third−generation drugs (20 µg ethinyl estradiol and 150 µg desogestrel). The influence of the second−generation hormonal contraception on the reproductive health of overweight women has been studied, the nature and frequency of adverse reactions have been determined, its advantages and disadvantages have been assessed, and the parameters of the hemostasis system and blood lipid spectrum have been compared. The dynamics of changes in the level of blood pressure, HOMA index in the patients using different methods of hormonal contraception has been shown. The need for a comprehensive examination of overweight women to choose the method of hormonal contraception has been emphasized. The second−generation hormonal contraceptives have been determined to be highly effective in preventing unwanted pregnancies in overweight women of childbearing age, especially if they have financial problems. The effect of the hormonal contraceptive with desogestrel on the blood coagulation system in women was also noted, which was demonstrated by a decrease in the clotting time by the end of the study and an increase in the prothrombin index and fibrinogen. Therefore, it was found that for this group of women it was desirable to use the second−generation hormonal contraceptives, the advantage of which was a lower risk of thrombosis.

Key words: hormonal oral contraceptives, overweight, women.

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