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№3' 2019

INFECTIOUS DISEASES

International Medical Journal, Vol. 25., Iss. 3, 2019, P. 79−82.


DOI (https://doi.org/10.37436/2308-5274-2019-3-15)

CHRONIC HCV-INFECTION AS A PREDICTOR OF DISEASE SEVERITY (case study)


Nataliia Volodymyrivna Shepylieva, Alla Oleksandrivna Shvaichenko

Kharkiv Medical Academy of Postgraduate Education, Ukraine

A global problem for humanity is the wide spread of HCV carriers worldwide. To address this, the WHO has developed a global strategy for the health sector to eliminate viral hepatitis and has set the following goals: to reduce the number of new cases of chronic hepatitis B and C by 90 % by 2030 as well as to reduce the quantity of death from these infections by 65 %. It is emphasized that the development of infectious or somatic disease on the background of chronic viral hepatitis requires a more careful approach and thorough medical correction, as their course and prognosis can be significantly aggravated. The case of viral hepatitis A, which occurred on a background of previously undiagnosed HCV infection and resulted in a death, has been described. Thus, previously undiagnosed HCV infection exacerbated the course of a self−eliminating disease, such as hepatitis A, and resulted in a death. Therefore, expanding the screening for viral hepatitis will allow identifying infected individuals and conducting antiviral therapy and preventive measures, which will reduce the incidence and mortality rates.

Key words: viral hepatitis A, viral hepatitis C, chronic HCV−infection, diagnosis, treatment, outcome.


REFERENCES


1. World Health Organization. Global Hepatitis Report, 2018. Geneva: WHO, 2018.− URL: http://apps.who.int/iris/bitstream/handle/10665/255017/WHO−HIV−2018.06−eng.pdf?sequence=1

2. VOZ. Gepatit S. Osnovnye fakty. 2 oktyabrya 2018 g.− URL: http://www.who.int/ru/news−room/fact−sheets/detail/hepatitis−c

3. Progress report on access to hepatitis C treatment. Focus on overcoming barriers in low− and middle−income countries. March 2018. World Health Organization 2018.− URL: http://apps.who.int/iris/bitstream/handle/10665/260445/WHO−CDS−HIV−18.4−eng.pdf?sequence=1

4. World Health Organization. Global Hepatitis Report, 2017. Geneva: WHO, 2017.− URL: http://apps.who.int/iris/bitstream/handle/10665/255017/WHO−HIV−2017.06−eng.pdf?sequence=1

5. VOZ. Gepatit S. Osnovnye fakty. 2 oktyabrya 2018 g.− URL: http://www.who.int/ru/news−room/fact−sheets/detail/hepatitis−c

6. Polaris Observatory HCV Collaborators. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study // Lancet Gastroenterol Hepatol.− 2017.− Vol. 2 (3).− P. 161−176.

7. Marcellin R. Hepatitis B and Hepatitis C in 2009 / R. Marcellin // Liver Int.− 2009.− Vol. 29 (1).− R. 1−8.

8. Acute hepatitis C virus infection: a chronic problem / J. T. Blackard, M. T. Shata, N. J. Shire, K. E. Sherman // Hepatology.− 2008.− Vol. 47 (1).− P. 321−331.

9. Fulminant hepatitis associated with hepatitis A virus superinfection in patients with chronic hepatitis C / S. Vento, T. Garofano, C. Renzini [et al.] // N. Engl. J. Med.− 1998.− Vol. 338.− P. 286−290.

10. Burnevich E. Z. Pechenochnaya entsefalopatiya pri tsirroze pecheni / E. Z. Burnevich, T. N. Lopatkina, M. S. Krasnova // Gepatologicheskii forum.− 2008.− № 2.− S. 19−24.

11. Klyuchareva A. A. Ful'minantnyi gepatit virusnoi etiologii / A. A. Klyuchareva.− Minsk: BelGIUV, 2000.− 200 s.

12. Malii V. P. Ostraya pechenochnaya nedostatochnost' u bol'nykh virusnymi gepatitami i gerpesvirusnymi infektsiyami / V. P. Malii, D. V. Mal'tsev.− Khar'kov: Shchedra sadiba plyus, 2014.− 216 s.

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