International Medical Journal, Vol. 25., Iss. 2, 2019, P. 70−75.
STATE OF LIPID PEROXIDATION AND ANTIOXIDANT SYSTEM IN PATIENTS WITH CHICKEN POX
V. N. Karazin Kharkiv National University
Kharkiv Medical Academy of Postgraduate Education, Ukraine
In order to study in dynamics the state of lipid peroxidation and antioxidant system in patients with varicella, depending on the disease severity, their complex examination was carried out, which included clinical, biochemical and instrumental methods. The state of lipid peroxidation in varicella patients was judged by the examining of serum diene conjugates, malonic dialdehyde and total oxidative activity of blood plasma. The state of antioxidant system was found by the total antioxidant activity of blood plasma and erythrocytes, activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase of erythrocytes, glutathione peroxidase, glutathione reductase of blood plasma, total glutathione content, oxidative and restorative glutathione of blood plasma. The results of the study of indices of oxidative and antioxidant systems in patients with chicken pox indicated that as the severity of the disease enhances, the content of primary diene conjugates and secondary malonic dialdehydes of lipid peroxides and the total oxidative activity of blood plasma increases, indicating the activation of lipid peroxidation. The data obtained confirm the advisability of using antioxidants in the treatment of chicken pox. Patients who received in addition to the combined therapy the antioxidants, i.e. mexidol and tocopherol at earlier terms oxidative activity of blood plasma, the blood levels of conjugated dienes and malondialdehyde, there was decreased the oxidative activity of blood plasma, content of diene conjugates and malone aldehyde, antioxidant activity of blood plasma and erythrocytes, activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and the concentration of reduced glutathione were increased, that was accompanied with by a decrease in intoxication and clinical improvement.
Key words: chicken pox, lipid peroxidation, antioxidants.