International Medical Journal, Vol. 25., Iss. 2, 2019, P. 53−56.
PROBLEM OF NEUROGENESIS IN THERAPY OF NEUROINFLAMMATORY/NEURODEGENERATIVE PROCESS
SI "Institute of Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine
At early stages of demyelinating and degenerative diseases of the central nervous system, degenerative changes are partly reversible, requiring improvements in diagnostic measures, the emergence of alertness among neurology doctors and general practitioners. An analysis of the current state of the study of the central nervous system degenerative and inflammatory diseases revealed a pressing problem of an adequate comprehensive medical care for these patients. The new therapeutic strategy should be aimed at "neuroprotection", which will trigger stimulation of neurogenesis, angiogenesis, restoration of structures and functions of synaptic apparatus, formation of dendritic networks. It has been shown that the autoimmune inflammatory disease of multiple sclerosis also has a degenerative component. In the system of therapeutic measures of the disease of Wilson−Konovalov, in addition to the obvious toxic effects of the copper itself, it is advisable to consider the vascular factor as one of the components of adaptive counteraction to the degenerative process. Taking into account the knowledge about the inflammatory factor negative effect on neurogenesis and adaptive possibilities of the nervous system, even the minimal signs of active inflammation in the central nervous system (as well as the situation of radiologically isolated syndrome) require the prescribing of pulse therapy with glucocosteroids. A hypothesis is made that glucocorticosteroids, although having a direct negative effect on neurogenesis, can indirectly positively influence the inhibition of inflammation and decrease in edema. Addition of therapy based on the concept of "guided neuroplasticity" can be a significant contribution to the system of therapeutic measures of neuro−inflammatory and neurodegenerative diseases of the central nervous system.
Key words: neurogenesis, neuroinflammation, neurodegeneration, glucocorticosteroids