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№4' 2018

THERAPY

International Medical Journal, Vol. 24., Iss. 4, 2018, P. 15−19.

CHANGES IN LIPID METABOLISM MARKERS IN PATIENTS WITH INCREASED BODY MASS INDEX WITH POLYTRAUMA

Kharkiv National Medical University, Ukraine

The background of violations of the body's functions at an elevated body mass index is presented by metabolic disturbances, including the lipid ones. The combination of anatomical and pathophysiological features of the body of patients suffering from obesity creates preconditions for the complicated course of the disease, especially in patients with polytrauma, who are on the verge of functional abilities against the background of subjective well−being of most vital functions for a long time after being admitted to a hospital. Studies of lipids in patients with obesity are important due to the presence of accompanying pathology that affects their condition on the background of a traumatic illness. In order to analyze the dynamics of lipid markers markers in patients with elevated body mass index during a polytrauma, 224 patients with ISS and ARA?NE II starting dates for the period from the first month of treatment to one year from the time of injury were examined. The level of total cholesterol, triglycerides, high density lipoprotein cholesterol and the atherogenicity factor have been studied. The study was conducted on days 1, 3, 7, 14, 30 and 360 from the moment of receiving a polytrauma. It was found that the indices of total cholesterol, triglycerides, high−density lipoprotein cholesterol, and the coefficient of atrogenicity directly influence the course of traumatic illness in patients with an increased body mass index, the degree of severity of which in the conditions of homogeneity of the damages received and the same range of their severity on the scale of the RAILY II depends on the index body mass at the time of the patient's arrival to the hospital.

Key words: lipid metabolism, increased body mass index, polytrauma.