International Medical Journal, Vol. 24., Iss. 3, 2018, P. 45−49.
SYSTEMIC DISORDERS IN PATIENTS WITH MULTIPLE SCLEROSIS
Kharkiv National Medical University, Ukraine
The review presents main provisions of the concept confirming that multiple sclerosis (MS) is a systemic disease. The information confirming the disturbance of the immune system and factors of nonspecific protection, the sequence of their emergence with participation of cellular and humoral links of immunity in the various types of the disease course is given. The role of immune disturbances in initiation of proinflammatory cytokines is indicated. Risk factors of MS development (viral and other chronic infections, improper feeding, namely vitamin D insufficiency, frequent labor, stresses, contamination of the environment, harmful habits, genetic predisposition) are described. The association of the immune system with the state of blood brain barrier (BBB), cerebral vascular system, depending on the age and sex, autonomous nervous system (the state of its supra−segmental and segmental links), (prolongation of cardiac intervals, decrease of their heart rhythm variability indices (HRV) with the tension of regulatory mechanisms and activity of subcortical sympathetic centers, the increase of more pronounced neurologic deficiency in the great vagal activity) ensuring compensatory−trophic influences both on the various structures of the brain and the state of other organs and systems are stated. Variants of disturbance of "wake−sleep" cycle and the changes of bioelectrogenesis of the brain depending on the types of MS course are described. The data on MS as a multi−systemic disease with a great percentage of development of co−morbid conditions of the cardiovascular, endocrine, urinary, osteomuscular systems, connective tissue, gastrointestinal tract and respiratory organs are given.
Key words: multiple sclerosis, immune, autonomic, vascular systems, blood−brain barrier, comorbid states.