ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 24., Iss. 2, 2018, P. 41−45.
GENERAL CLINICAL, BIOCHEMICAL PARAMETERS AND PERIPHERAL BLOOD HORMONE LEVEL IN WOMEN AT OVARIAN HYPERSTIMULATION SYNDROME
Zaporizhzhia State Medical University
Zaporizhzhia National University, Ukraine
Introduction into the clinical practice of auxiliary reproductive technologies has fundamentally altered the chances of overcoming the factors of infertile marriage. However, the use of controlled ovarian stimulation as infertility treatment may be complicated by development of ovarian hyperstimulation syndrome, characterized by a wide range of clinical and laboratory manifestations. The main cause of this syndrome is the phenomenon of "increased vascular permeability", the trigger of which leads to fluid transduction. To analyze general clinical, biochemical, hormonal blood parameters, as well as ultrasonography findings of women participating in the short−term protocol for in vitro fertilization, for its timely, individual, adequate correction and complex prevention of ovarian hyperstimulation syndrome, women aged 2−45 were examined. During the study history taking, clinical and biochemical examination, ultrasonography were used. The results of the study indicated a positive statistically significant relationship between the number of follicles and the content of leukocytes, monocytes, progesterone and estradiol, the number of large classes of lymphocytes, and a negative relationship with the level of reaction of lymphocyte blast transformation at the risk of ovarian hyperstimulation syndrome development. It was determined that the risk factors for ovarian hyperstimulation syndrome were the age of the woman under 35, hyperprolactinemia, sclerotic ovarian syndrome, primary infertility. Consequently, a comprehensive survey of women allows determining the risk of developing ovarian hyperstimulation syndrome in order to correct the protocol of controlled ovulation stimulation, timely rendering medical aid at the first manifestations of complications and its prevention in the programs of extracorporeal fertilization.
Key words: ovarian hyperstimulation syndrome, peripheral blood, leukogram, biochemical indices, hormones.