ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 24., Iss. 2, 2018, P. 35−40.
АROMATHASE ACTIVITY AS AN OBJECTIVE MARKER OF NECESSITY OF CRYOTHERAPY OF UTERINE CAVITY IN HYPERPLASTIC ENDOMETRIAL PROCESSES
Kharkiv National Medical University, Ukraine
Endometrial hyperplasia is accompanied by excessive proliferation of stromal and glandular components of the mucous membrane of the uterine cavity in connection with the presence in it of specific receptors. Aromatase is a unique enzyme complex that is responsible for the synthesis of estrogens in the female organism. A promising trend in clinical medicine is the determination of the activity of aromatase, not only in the endometrium, but also in the tissues and organs that participate in the production of estrogens. With the aim to develop a method for clinical and laboratory evaluation of aromatase activity in women with endometrial hyperplasia as a marker for determining the risk of cancer and the choice of pathogenetically based medical tactics the patients with glandular and adenomatous disease were examined. To determine the degree of severity of the pathological process and select the optimal and pathogenetically substantiated therapeutic tactics, the coefficient of aromatase activity was evaluated. If the coefficient exceeded 10.0 units, in order to prevent the risk of relapse and possible cancer, it is necessary to recommend ablation of the endometrium with cryosurgical treatment of the uterine cavity. When analyzing the obtained results, it can be concluded that 6 months after ablation of the endometrium and cryosurgical treatment of the uterine cavity in patients with endometrial hyperplasia, the concentration of estrone and estradiol did not differ from those of the control group of women with a normal endometrial structure. The suggested method can be introduced as a marker for determining the severity of the pathological process.
Key words: endometrial hyperplasia, cryosurgical treatment of the uterine cavity, blood hormones, aromatase activity.