ARCHIVEOBSTETRICS AND GYNECOLOGY
International Medical Journal, Vol. 24., Iss. 1, 2018, P. 47−51.
THE COURSE AND OUTCOME OF PREGNANCY IN WOMEN WITH OVARIAN ENDOMETRIOSIS AFTER APPLICATION OF ASSISTED REPRODUCTIVE TECHNOLOGIES
Kharkiv National Medical University, Ukraine
Recent studies have demonstrated that in patients with endometriosis the frequency of pregnancy is significantly lower than in healthy women. The association of endometriosis and infertility is well known, but the mechanisms of impaired fertility, approaches to treatment, analysis of the course of pregnancy, obtained with the help of assisted reproductive technologies in patients with this pathology, have not been fully investigated. In order to improve the differentiated tactics of infertility treatment in women with ovarian endometriosis, the course of pregnancy, depending on the method of assisted reproductive technologies and administration of vitamin D were investigated. Depending on the treatment method, the patients with endometriosis of the ovaries were divided into three groups: patients with extracorporeal fertilization performed after surgical treatment; women with controlled ovarian stimulation prior to surgical treatment of endometriomas and embryo transfer in the cryopreservation cycle was performed after endometriomyctomy; women with in vitro fertilization program, treated similarly to the second clinical group, but who were additionally administered vitamin D (cholecalciferol) 5000 IU/day. The effectiveness of the use of assisted reproductive technologies in women with endometriosis of the ovaries was also affected by the immune and endothelial status, the level of vitamin D, the time of in vitro fertilization (before or after surgery). These studies showed that infertility treatment in women with ovarian endometriosis with the use of assisted reproductive technologies before endometriomectomy against a background of vitamin D intake can significantly increase the effectiveness of in vitro fertilization and improve the course of subsequent pregnancy.
Key words: endometriosis, infertility, assisted reproductive technologies, pregnancy, vitamin D.