International Medical Journal, Vol. 23., Iss. 3, 2017, P. 68−73.
EFFECTIVENESS OF CALCIUM HOPANTENATE IN TREATMENT OF COGNITIVE IMPAIRMENTS AT EPILEPSY
Kharkiv National Medical University, Ukraine
Epilepsy is a disease that manifests by repeated unprovoked attacks caused by excessive neuronal discharges in the cerebral cortex. Apart from the seizures, the main characteristics of epilepsy include cognitive disorders. They are defects of memory, attention, speech, orientation, cognition, intellect, agnosia and apraxia. Patients with epilepsy have to take anticonvulsant therapy for a long period of time, which alone can have a negative impact on the cognitive field. To evaluate the effectiveness of the calcium hopantenate drug (Kognum) in the treatment of cognitive disorders at epilepsy the patients with generalized tonic−clinic convulsions and secondary generalized seizures, who received anticonvulsant monotherapy with valproic acid drugs and lamotrigine group for more than five years were examined. All patients were administered Kognum for three months. Before and after administration of Kognum to assess the degree of cognitive impairments, Mini−mental state examination and Wisconsin card sorting test (WCST) were used. Kongum demonstrated high effectiveness in treatment of cognitive disorders at epilepsy after a single three−month course both in patients with generalized tonic−clinic seizures, and with secondary generalized seizures. Kongum effectively interacted with anticonvulsants (valproic acid drugs and lamotrigine group). The drug did not cause significant side effects, which indicates the safety and appropriateness of its administration with antiepileptic drugs. Today, prevention of cognitive disorders should be considered in the context of the most important tasks of pharmacotherapy of epilepsy. Further accumulation of the experience, as well as the use of GACS drugs as an optimal tool for solving this problem, will contribute to improving the quality of life of patients with epilepsy and their maximum medical and social adaptation.
Key words: epilepsy, cognitive disorders, GABA, kognum.