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№3' 2017
CARDIOLOGYInternational Medical Journal, Vol. 23., Iss. 3, 2017, P. 5−10.
BLOOD PLASMA LIPIDS AND HORMONAL CHANGES IN PATIENTS WITH CORONARY ATHEROSCLEROSIS
Kharkiv Medical Academy of Postgraduate Education
V. N. Karazin Kharkiv National University
At present cardiovascular diseases ae the main cause of disability and mortality all over the world, including Ukraine, with that coronary artery disease is responsible for about 2/3 of cardiovascular deaths. Clinical and experimental research have shown that lipid metabolism disorders play an important role in atherosclerosis pathogenesis, which necessitates investigation of the factors participating in lipid metabolism regulation in patients with atherosclerosis of the coronary vessels. From this perspective, the study of the role of hormonal factors (thymus, thyroid, glands, adrenals, pancreas) in lipid metabolism disorders is important. For this purpose, complex investigation of the patients with coronary atherosclerosis was performed using general clinical methods, electrocardiography in 12 deviations, circadian monitoring, veloergometry, ultrasonography of the heart, selective coronaroangiography, biochemical blood test. The findings of the research suggest that the patients with increased degree of coronary stenosis have increased blood plasma low density lipoprotein cholesterol concentration, low high density lipoprotein cholesterol concentration, and increased atherogenicity coefficient. Hyperlipedemia was diagnosed in the majority of patients and was associated with increased level of low density lipoprotein cholesterol concentration. Direct correlation was revealed between the concentration of blood plasma lipoproteins (a) and the degree of atherosclerotic involvement. It was determined that increased of blood lipoproteins (a) level is due to the low molecular isoforms B, S1 and S2 with high athero− and thrombogeneity. To optimize the diagnosis and treatment of the patients with coronary atherosclerosis it is necessary to determine blood low density lipoprotein cholesterol and lipoproteid (a) as most atherogenic factors as well as functional state of the hormones taking part in metabolic processes regulation in the human organism.
Key words: atherosclerosis, lipids, hormones, lipoprotein (a), treatment.