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№1' 2017

INFECTIOUS DISEASES

International Medical Journal, Vol. 23., Iss. 1, 2017, P. 77−88.

COMPARATIVE ASSESSMENT IMMUNITY CHANGES IN PATIENTS WITH CHRONIC ACQUIRED TOXOPLASMOSIS AT DIFFERENT TYPES OF THERAPY

Kharkiv Medical Academy of Postgraduate Education, Ukraine

The problem of toxoplasmosis is relevant due to the disease prevalence in the world. The lack of universal treatment protocols necessitates an individual approach to the use of different forms of therapy for chronic acquired toxoplasmosis. For this purpose we performed comparative assessment of the dynamics of indicators of immunological protection in patients under the influence of various types of complex therapy. Diagnostic criteria of exacerbation stage of the disease were the clinical symptoms and instrumental findings. The efficiency of complex treatment of exacerbation stage of chronic acquired toxoplasmosis was studied using antiprotozoal therapy with a combined drug pyrimethamine + sulfadoxine, specific immunoglobulin against human Toxoplasma and their combination on the basis of investigation of the dynamics of clinical and laboratory, instrumental and immunological data. In this disease, the effect of the therapy was assessed no earlier than one month after the comprehensive treatment, and then 6 months after it. The maximum therapeutic effect was determined from the 6th month of treatment onset. Pronounced dynamics of indicators was noted in patients receiving combination therapy, moderate −− replacement therapy with immunoglobulin against Toxoplasma gondii, and inconsiderable −− in patients treated with pyrimethamine + sulfadoxine.

Key words: chronic acquired toxoplasmosis, diagnosis, treatment, T− and B−immunity systems, findings of immunological protection of the patients.