ARCHIVEOBSTETRICS AND GYNECOLOGY
DIFFERENTIAL ULTRASONOGRAPHY CRITERIA AND TREATMENT OF NODULAR UTERINE LEIOMYOMA IN WOMEN OF REPRODUCTIVE AGE
Kharkiv Medical Academy of Postgraduate Education, Ukraine
In the structure of hyperplastic processes of the myometrium nodular leiomyoma occurs in 25−30 % of women of reproductive age and is the most common benign tumor of the female reproductive system. Today the leading role in the diagnosis of hyperplastic processes of the myometrium is played by ultrasound color Doppler mapping. To study the differential criteria of ultrasonography and clinical efficacy of microencapsulated diindolylmethane (DIM), a derivative of indole−3−carbinol, Balansid ™ (Naari, Switzerland) as monotherapy for small nodular leiomyoma of the uterus, a clinical ultrasound investigation was done in women of reproductive age. The analysis of the results of clinical investigation and the findings of transvaginal ultrasonography with color Doppler shows that Balansid ™ produces a pronounced anti−proliferative effect on the cells of the myometrium due to direct interaction with estrogen receptors, normalizes the metabolism of estrogen, stimulates the process of phosphorylation of estrogen−receptor proteins and aid in production of effective 2−hydroximetabolotes. Balansid administration as monotherapy in a cyclic mode at least for 6 months in women of reproductive age with small nodular uterine leiomyoma is pathogenetically substantiated and appropriate. The drug is safe, has no side effects and can be recommended for use in clinical practice.
Key words: leiomyoma of the uterus, transvaginal echosonography, clinical symptoms and signs, Balansid(tm), clinical efficacy, women of reproductive age.