THE EFFECT OF METABOLIC SYNDROME ON PROSTATIC CANCER DEVELOPMENT
Kharkiv Medical Academy of Postgraduate Education, Ukraine
At present, prostate cancer is one of the most socially significant oncological diseases in the world. An equally important problem is the high incidence of obesity and metabolic syndrome in the majority of economically advanced countries. According to the concept of metabolic syndrome, obesity, mainly of android type, hypertension, dyslipidemia, impaired glucose tolerance are the links in a chain of metabolic disorders, and the leading ones are insulin resistance and compensatory hyperinsulinemia. In the recent foreign literature, clinical features of prostate cancer in men with excessive body weight have been fearured. The study of such aspects of metabolic syndrome as blood pressure, increased body weight, increased levels of uric acid and insulin resistance allowed to regard them as risk factors for the development of prostate cancer. However, additional factors of medically controlled hypertension, increased levels of high−density lipid and triglyceride levels significantly affect the development of aggressive prostate cancer and mortality. Changes in the lifestyle and dietary recommendations, along with the control of the body weight, can help to stabilize the severity of metabolic syndrome and prevent development of prostate cancer.
Key words: prostate cancer, metabolic syndrome, study.