International Medical Journal, Vol. 22., Iss. 3, 2016, P. 5−10.
RELATIONSHIP BETWEEN HIGH-SENSITIVITY C-REACTIVE PROTEIN AND INTRACARDIAC HEMODINAMIC PARAMETERS IN PATIENTS WITH MYOCRDIAL INFARCTION
Kharkiv Medical Academy of Postgraduate Education, Ukraine
Inflammation plays the key role in pathogenesis of myocardial infarction and is a necessary stage for healing. High−sensitivity C−reactive protein is the laboratory marker that can reflect the input of inflammation during the disease course. Six hours after the disease onset high−sensitivity CRP concentration rises sharply, which reflects the degree of the inflammatory process due to myocardial necrosis. The aim of the work was to evaluate the factors which affect the degree of inflammation in patients with myocardial infarction and possible relationship between high−sensitivity C−reactive protein level and intracardiac hemodynamic parameters. All patients underwent intravenous fibrinolysis. Cardiac ultrasound was performed on day 3−14 of the disease. Blood sampling for high−sensitivity C−reactive protein was performed on admission, during the first 6 hours of the disease onset. The level of CRP was determined using increased latex immunoturbodimetric analysis. Strong positive correlation between high−sensitivity C−reactive protein level and the history of type 2 diabetes mellitus and with the time to fiblinolysis; weak positive correlation between high−sensitivity C−reactive protein level and LV end−diastolic diameter were revealed. Patients from the highest quartile had higher mean end−diastolic and end−systolic LV diameter than the patients in groups 1 and 2. Valid regression model in which high−sensitivity C−reactive protein level accounted for 7.3 % of end−systolic LV diameter increase and for 8.9 % of end−diastolic LV diameter increase was obtained. High−sensitivity C−reactive protein level is an independent factor related to end−diastolic and end−systolic LV diameters in patients with ST elevation myocardial infarction.
Key words: C−reactive protein, myocardial infarction, diabetes mellitus, intracardiac hemodynamics.