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№2' 2016
DERMATOVENEREOLOGYInternational Medical Journal, Vol. 22., Iss. 2, 2016, P. 70−76.
CLINICAL AND MORPHOLOGICAL CHARACTERISTICS OF THE SKIN OF MIDDLE-AGED WOMEN WITH HYPERTENSION
Center for Cosmetology and Plastic surgery, Ekaterinburg, Russian Federation
Ural State Medical Academy, Ministry of Health of Russia, Yekaterinburg, Russian Federation
Kharkiv Regional Clinical Dispensary of Radiation Protection, Ukraine
A clinical and morphological study of 108 middle−aged women with arterial hypertension who referred to the clinic for plastic surgery was performed to assess the clinical morphological characteristics of the skin. Morphological examination of skin biopsy specimens from behind the ear using staining with hematoxylin−eosin, picro fuchsin (Van Gieson), fuchselin (Weigert) for elastics, revealed in these patients the changes, particularly expressed in the microvasculature in the form of dystonia: uneven lumens in the arterioles due to spasms and ectasia, destructive changes of the walls (mucoid and fibrinoid swelling up to necrosis), plasma impregnation, formation of blood clots and microaneurysms, hyalinosis, endothelium discomplexity. Marked degenerative changes in the elastic and collagen fibers with violation of their relationship, uneven thickness and tortuosity of the basement membrane, variability in different layers of epidermis cells with uneven accumulation of melanin and hemosiderin were revealed in the dermis. More pronounced manifestations of vascular and degenerative changes were present in older individuals, which confirms the validity of the clinical and morphological patterns and causal relationship of vascular changes and parenchymal cells. This should be considered by clinicians at all stages of patient management, i.e. pre−, post−operative and rehabilitation.
Key words: patients with arterial hypertension, skin, microcirculation, morphological features, biopsy material.