International Medical Journal, Vol. 22., Iss. 2, 2016, P. 5−10.
AMBULATORY BLOOD PRESSURE MONITORING IN HYPERTENSIVE PATIENTS WITH OVERWEIGHT AND OBESITY
Kharkiv National Medical University, Ukraine
The purpose of the work was to analyze the characteristics of ambulatory blood pressure monitoring (ABPM) in hypertensive patients with overweight and obesity. A total of 76 patients (35 men and 41 women) with essential hypertension (EH) aged 38−76 who received antihypertensive therapy with groups 1−3 of drugs were observed. Depending on the body mass index, the patients were divided into 4 groups: group 1 −− patients with normal body weight, group 2 −− patients with overweight; group 3 −− patients with hypertension and grade 1obesity, group −− 4 patients with hypertension and grade 2−3 obesity. Analysis of ABPM parameters in hypertensive patients with obesity and overweight revealed significantly higher index area and normalized load index area of diastolic pressure, as well as the value of the daytime and nighttime variation in diastolic blood pressure. The analysis of indicators reflecting the dynamics of the blood pressure in the morning revealed statistically significant increase in «adverse» morning hours index values in groups of hypertensive patients with grade 1−3 obesity compared to the patients with normal weight and overweight. Hypertension in overweight and obesity was associated with changes in the biological circadian rhythm of blood pressure to «non−dipper» type with lack of its adequate reduction at night. The revealed features of the ambulatory blood pressure monitoring parameters indicate an increased risk of early target organ damage and development of cerebral vascular events in these patients.
Key words: ambulatory blood pressure monitoring, hypertension, obesity.