International Medical Journal, Vol. 22., Iss. 2, 2016, P. 11−13.
THE ROLE OF G-308A VARIANT OF TUMOR NECROSIS FACTOR-α GENE IN DEVELOPMENT OF OBESITY IN PATIENTS WITH CORONARY ARTERY DISEASE
Kharkiv National Medical University, Ukraine
The aim of the work was to estimate the value of the polymorphic locus G−308A gene of tumor necrosis factor−α in development of obesity in patients with coronary artery disease. Complex examination of 222 patients with coronary artery disease, who were treated at cardiology department of Kharkiv City Clinical Hospital № 27, was performed. All patients with coronary artery disease and obesity were divided into three groups. Group 1 included patients with grade 1 obesity (n = 80), group 2 −− patients with grade 2 obesity (n = 71), and group 3 patients with grade 3 obesity (n = 71). Thirty−five healthy persons saved as controls. Statistical analysis of the results was performed using software Statistica (StaSoftInc, USA). Mean, standard deviation and significance level by Pearson at p < 0.05 were calculated. Reducing the frequency of detection of the genotype G/G polymorphic locus G−308A gene of tumor necrosis factor−α is associated with development of obesity in patients with coronary artery disease. In patients with coronary artery disease and obesity, increase in the detection rate of A allele and genotype A/A polymorphic locus G−308A gene of tumor necrosis factor−α and decrease in G allele was associated with an increase in the body weight.
Key words: tumor necrosis factor−α gene, coronary artery disease, obesity.