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№4' 2015

OBSTETRICS AND GYNECOLOGY

IMMUNITY STATE IN FERTILE WOMEN WITH CHRONIC RECURRENT VAGINAL CANDIDIASIS

O. V. DOLENKO

Kharkiv Medical Academy of Postgraduate Education, Ukraine

The present time is marked by rapid growth of non−specific infectious and inflammatory diseases of the lower genitals of women of reproductive age, including chronic recurrent vaginal candidiasis (HRVC) making 35 % in the overall dysbiotic process s of the vaginal biotope. Modern investigations have established that a chronic relapsing course of vaginal candidiasis is caused by the features of anti−infection protection of the genital tract; the trigger of the disease is reduction of the resistance of the host organism as a whole. The humoral link of local immunity and humoral and cellular link of systemic immunity were studied in 40 women of reproductive age with HRVC. The control group consisted of 30 women with vaginal normocenosis. Assessment of the findings of humoral immunity investigation demonstrated increase in local levels of IgA, IgG, decreased concentrations of Gimp, IgA and lysozyme, which suggested disorders of the non−specific immune response in anti−infection protection of the genital tract. The study of cellular and humoral systemic immunity revealed decreased subpopulations of CD3+, CD4+, CD8+, immunoregulatory index (CD4+/ CD8+), NK (CD16+), percentage of phagocytosis and CIC at unchanged rates of IgA, IgM, IgG, indicating disorders in the immune response regulation in this form of dysbiosis. These findings suggest the presence of imbalance of immunoregulatory mechanisms regulating anti−infection protection of the genital tract responsible for the chronic recurrent course of vaginal candidiasis and promoting reduction of the overall immunoreactivity of the organism in women.

Key words: local and systemic immunity, chronic recurrent vaginal candidiasis, fertile age.

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