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№2' 2015
DERMATOVENEREOLOGYInternational Medical Journal, Vol. 21., Iss. 2, 2015, P. 71−74.
INVESTIGATION OF BIOLOGICAL MOLECULES IN THE RHYTHM OF HAIR FOLLICLES IN PATIENTS WITH ALOPECIA AREATA
Republican Specialized Scientific and Practical Medical Center of Dermatology and Venereology of Ministry of Health of Uzbekistan, Tashkent, Uzbekistan
The problem of hair loss in working−age population is not only of medical but also social significance. The trend to growth of the rate of torpidly occurring forms of the disease that are resistant to therapy has been observed. The study of fibroblast growth factor bFGF, and FasL apoptosis factor in patients with alopecia areata can help to improve the treatment of this disease. Fibroblast growth factor bFGF, and apoptosis FasL factor were investigated in the blood of patients with alopecia areata and healthy individuals by ELISA using test systems Sigma (Germany). The results showed that the concentration of basic fibroblast growth factor bFGF in the blood of patients with alopecia areata was significantly reduced compared with those in healthy subjects and the concentration of apoptosis FasL factor was significantly increased. The changes in the indices of growth factors and apoptosis correlated with the severity of alopecia areata. The study suggests that the proteins of the FGF family and FasL are responsible for the fine adjustment of the phases of the life cycle of the hair follicles. Further studies aimed at regulating the concentration of these proteins in the hair follicles may become the basis for the improvement of treatment of alopecia areata.
Key words: alopecia, cytokines, dermatoscopy.